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94 results
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In vitro-in vivo extrapolation of hepatic clearance involving active uptake: theoretical and experimental aspects.
Webborn PJ, Parker AJ, Denton RL, Riley RJ. Webborn PJ, et al. Among authors: riley rj. Xenobiotica. 2007 Oct-Nov;37(10-11):1090-109. doi: 10.3109/00498250701557266. Xenobiotica. 2007. PMID: 17968738 Review.
Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
Weaver R, Graham KS, Beattie IG, Riley RJ. Weaver R, et al. Among authors: riley rj. Drug Metab Dispos. 2003 Jul;31(7):955-66. doi: 10.1124/dmd.31.7.955. Drug Metab Dispos. 2003. PMID: 12814974
Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4.
Wilby AJ, Maeda K, Courtney PF, Debori Y, Webborn PJ, Kitamura Y, Kusuhara H, Riley RJ, Sugiyama Y. Wilby AJ, et al. Among authors: riley rj. Drug Metab Dispos. 2011 Dec;39(12):2361-9. doi: 10.1124/dmd.111.041814. Epub 2011 Sep 22. Drug Metab Dispos. 2011. PMID: 21940906
Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA.
Williamson B, Soars AC, Owen A, White P, Riley RJ, Soars MG. Williamson B, et al. Among authors: riley rj. Xenobiotica. 2013 Oct;43(10):920-31. doi: 10.3109/00498254.2013.776194. Epub 2013 Mar 6. Xenobiotica. 2013. PMID: 23461378
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance.
Soars MG, Burchell B, Riley RJ. Soars MG, et al. Among authors: riley rj. J Pharmacol Exp Ther. 2002 Apr;301(1):382-90. doi: 10.1124/jpet.301.1.382. J Pharmacol Exp Ther. 2002. PMID: 11907196
Evaluation of the marmoset as a model species for drug glucuronidation.
Soars MG, Riley RJ, Burchell B. Soars MG, et al. Among authors: riley rj. Xenobiotica. 2001 Dec;31(12):849-60. doi: 10.1080/00498250110069690. Xenobiotica. 2001. PMID: 11780760
Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s.
McGinnity DF, Parker AJ, Soars M, Riley RJ. McGinnity DF, et al. Among authors: riley rj. Drug Metab Dispos. 2000 Nov;28(11):1327-34. Drug Metab Dispos. 2000. PMID: 11038161
Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.
Soars MG, Grime K, Riley RJ. Soars MG, et al. Among authors: riley rj. Xenobiotica. 2006 Apr;36(4):287-99. doi: 10.1080/00498250500446208. Xenobiotica. 2006. PMID: 16684709
The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions.
Grime K, Riley RJ. Grime K, et al. Among authors: riley rj. Curr Drug Metab. 2006 Apr;7(3):251-64. doi: 10.2174/138920006776359266. Curr Drug Metab. 2006. PMID: 16611020 Review.
Predicting drug pharmacokinetics in humans from in vitro metabolism studies.
McGinnity DF, Riley RJ. McGinnity DF, et al. Among authors: riley rj. Biochem Soc Trans. 2001 May;29(Pt 2):135-9. doi: 10.1042/0300-5127:0290135. Biochem Soc Trans. 2001. PMID: 11356141
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