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MELANOMA AND DYSPLASTIC NEVI DEVELOPMENT AFTER RANITIDINE/RILMENIDINE/OXONIDINE, LERCANIDIPINE, ROSUVASTATIN AND VERAPAMIL/TRANDOLAPRIL - NEW DATA/CASE SERIES. THE POTENTIAL ROLE OF NITROSAMINE/NDSRIS CONTAMINATION IN POLYMEDICATION AS SUBSTANTIAL SKIN CANCER TRIGGERING FACTOR.
Tchernev G, Naydekova N. Tchernev G, et al. Georgian Med News. 2023 Nov;(344):152-158. Georgian Med News. 2023. PMID: 38236117
However, the contribution of the currently presented new data (5 new patients) is also due to the establishment of the possible pathogenetic role (with respect to melanoma) of several completely new drugs, previously unknown to the scientific community (potentially/actually conta …
However, the contribution of the currently presented new data (5 new patients) is also due to the establishment of the possible pathogenetic …
New anti-aging strategies: a narrative review.
Stojić V, Štrbac T, Stanimirović A. Stojić V, et al. Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):159-164. Acta Dermatovenerol Alp Pannonica Adriat. 2023. PMID: 38126098 Free article. Review.
Calorie restriction mimetics include the activator of AMP-activated protein kinase (metformin) and inhibitor of mTOR (rapamycin), alongside rilmenidine, exhibiting both effects. Rosmarinic acid, a natural product, functions through its anti-glycation properties. ...
Calorie restriction mimetics include the activator of AMP-activated protein kinase (metformin) and inhibitor of mTOR (rapamycin), alongside …
Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine.
Yalçın MB, Bora ES, Çakır A, Akbulut S, Erbaş O. Yalçın MB, et al. Acta Cir Bras. 2023 Dec 1;38:e387823. doi: 10.1590/acb387823. eCollection 2023. Acta Cir Bras. 2023. PMID: 38055406 Free PMC article.
PURPOSE: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ). ...On the 30th day after STZ administration, electromyography (EMG) and motor function tests confirmed the pr …
PURPOSE: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes in …
Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma.
Wang XK, Zhang XD, Luo K, Yu L, Huang S, Liu ZY, Li RF. Wang XK, et al. BMC Gastroenterol. 2023 Jun 20;23(1):216. doi: 10.1186/s12876-023-02827-y. BMC Gastroenterol. 2023. PMID: 37340445 Free PMC article.
After that, candidate target drugs with potential clinical significance were identified: Thiamine, Cromolyn, Rilmenidine, Chlorhexidine, Sulindac_sulfone, Chloropyrazine, and Meprylcaine. ...
After that, candidate target drugs with potential clinical significance were identified: Thiamine, Cromolyn, Rilmenidine, Chlorhexidi …
Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor.
Bennett DF, Goyala A, Statzer C, Beckett CW, Tyshkovskiy A, Gladyshev VN, Ewald CY, de Magalhães JP. Bennett DF, et al. Aging Cell. 2023 Feb;22(2):e13774. doi: 10.1111/acel.13774. Epub 2023 Jan 20. Aging Cell. 2023. PMID: 36670049 Free PMC article.
The rilmenidine-induced longevity required the transcription factors FOXO/DAF-16 and NRF1,2,3/SKN-1. Furthermore, we find that autophagy, but not AMPK signaling, was needed for rilmenidine-induced longevity. Moreover, transcriptional changes similar to caloric restr …
The rilmenidine-induced longevity required the transcription factors FOXO/DAF-16 and NRF1,2,3/SKN-1. Furthermore, we find that autoph …
Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension.
Zicha J, Řezáčová L, Behuliak M, Vaněčková I. Zicha J, et al. Physiol Res. 2022 Dec 16;71(6):763-770. doi: 10.33549/physiolres.935041. Epub 2022 Nov 25. Physiol Res. 2022. PMID: 36426892 Free PMC article.
The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) through a reduction of brain sympathetic outflow but their chronic antihypertensive effects in rats with low-renin or high-renin forms of exper …
The agonists of alpha(2)-adrenergic receptors such as clonidine, rilmenidine or monoxidine are known to lower blood pressure (BP) thr …
Data mining methodology for response to hypertension symptomology-application to COVID-19-related pharmacovigilance.
Xu X, Kawakami J, Millagaha Gedara NI, Riviere JE, Meyer E, Wyckoff GJ, Jaberi-Douraki M. Xu X, et al. Elife. 2021 Nov 23;10:e70734. doi: 10.7554/eLife.70734. Elife. 2021. PMID: 34812146 Free PMC article.
Because these two medications are prescribed in diseases affecting pulmonary function and may be likely to emerge among the highest reported pulmonary ADEs, in fact, they serve to validate the methods utilized here. Conversely, doxazosin and rilmenidine were found to have …
Because these two medications are prescribed in diseases affecting pulmonary function and may be likely to emerge among the highest reported …
The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration.
Gunawan M, Low C, Neo K, Yeo S, Ho C, Barathi VA, Chan AS, Sharif NA, Kageyama M. Gunawan M, et al. Int J Mol Sci. 2021 Jul 6;22(14):7271. doi: 10.3390/ijms22147271. Int J Mol Sci. 2021. PMID: 34298888 Free PMC article.
Interestingly, in cultured neuroblastoma cells, we found that the mammalian target of rapamycin-independent autophagy activators, lithium chloride and rilmenidine, rescued these cells against proteasome inhibition-induced death. ...
Interestingly, in cultured neuroblastoma cells, we found that the mammalian target of rapamycin-independent autophagy activators, lithium ch …
Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice.
Perera ND, Tomas D, Wanniarachchillage N, Cuic B, Luikinga SJ, Rytova V, Turner BJ. Perera ND, et al. Neurobiol Dis. 2021 Jul;154:105359. doi: 10.1016/j.nbd.2021.105359. Epub 2021 Mar 30. Neurobiol Dis. 2021. PMID: 33798740 Free article.
Although rilmenidine treatment induced robust autophagy in spinal cords, this exacerbated the phenotype of TDP-43(WTxQ331K) mice, shown by truncated lifespan, accelerated motor neuron loss, and pronounced nuclear TDP-43 clearance. Importantly, rilmenidine significan …
Although rilmenidine treatment induced robust autophagy in spinal cords, this exacerbated the phenotype of TDP-43(WTxQ331K) mice, sho …
500 results