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Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Among authors: rimmington d. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS. Gulati P, et al. Among authors: rimmington d. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359686 Free PMC article.
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.
Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S, Gribble FM. Grosse J, et al. Among authors: rimmington d. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. doi: 10.1073/pnas.1411413111. Epub 2014 Jul 15. Proc Natl Acad Sci U S A. 2014. PMID: 25028498 Free PMC article. Clinical Trial.
Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.
Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP. Larder R, et al. Among authors: rimmington d. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15. Proc Natl Acad Sci U S A. 2017. PMID: 28811369 Free PMC article.
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S. Patel S, et al. Among authors: rimmington d. Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10. Cell Metab. 2019. PMID: 30639358 Free PMC article.
GDF15 mediates the effects of metformin on body weight and energy balance.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Coll AP, et al. Among authors: rimmington d. Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Nature. 2020. PMID: 31875646 Free PMC article. Clinical Trial.
FTO is necessary for the induction of leptin resistance by high-fat feeding.
Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS. Tung YC, et al. Among authors: rimmington d. Mol Metab. 2015 Feb 7;4(4):287-98. doi: 10.1016/j.molmet.2015.01.011. eCollection 2015 Apr. Mol Metab. 2015. PMID: 25830092 Free PMC article.
28 results