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Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.

Tough DF, Lewis HD, Rioja I, Lindon MJ, Prinjha RK. Tough DF, et al. Among authors: rioja i. Br J Pharmacol. 2014 Nov;171(22):4981-5010. doi: 10.1111/bph.12848. Br J Pharmacol. 2014. PMID: 25060293 Free PMC article. Review.

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Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.

Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D. Fu W, et al. Among authors: rioja i. Elife. 2014 Nov 19;3:e04631. doi: 10.7554/eLife.04631. Elife. 2014. PMID: 25407682 Free PMC article.

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Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.

Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Yoshida H, et al. Among authors: rioja i. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57. doi: 10.1073/pnas.1512081112. Epub 2015 Jul 27. Proc Natl Acad Sci U S A. 2015. PMID: 26216992 Free PMC article.

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BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells.

Li J, Ma J, Meng G, Lin H, Wu S, Wang J, Luo J, Xu X, Tough D, Lindon M, Rioja I, Zhao J, Mei H, Prinjha R, Zhong Z. Li J, et al. Among authors: rioja i. Stem Cell Res. 2016 Sep;17(2):212-221. doi: 10.1016/j.scr.2016.07.006. Epub 2016 Jul 20. Stem Cell Res. 2016. PMID: 27591477

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BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells.

Schilderink R, Bell M, Reginato E, Patten C, Rioja I, Hilbers FW, Kabala PA, Reedquist KA, Tough DF, Tak PP, Prinjha RK, de Jonge WJ. Schilderink R, et al. Among authors: rioja i. Mol Immunol. 2016 Nov;79:66-76. doi: 10.1016/j.molimm.2016.09.010. Epub 2016 Oct 3. Mol Immunol. 2016. PMID: 27710838

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Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

Schulz D, Mugnier MR, Paulsen EM, Kim HS, Chung CW, Tough DF, Rioja I, Prinjha RK, Papavasiliou FN, Debler EW. Schulz D, et al. Among authors: rioja i. PLoS Biol. 2015 Dec 8;13(12):e1002316. doi: 10.1371/journal.pbio.1002316. eCollection 2015 Dec. PLoS Biol. 2015. PMID: 26646171 Free PMC article.

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Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis.

Rioja I, Clayton CL, Graham SJ, Life PF, Dickson MC. Rioja I, et al. Arthritis Res Ther. 2005;7(1):R101-17. doi: 10.1186/ar1458. Epub 2004 Nov 19. Arthritis Res Ther. 2005. PMID: 15642130 Free PMC article.

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BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.

Wyspiańska BS, Bannister AJ, Barbieri I, Nangalia J, Godfrey A, Calero-Nieto FJ, Robson S, Rioja I, Li J, Wiese M, Cannizzaro E, Dawson MA, Huntly B, Prinjha RK, Green AR, Gottgens B, Kouzarides T. Wyspiańska BS, et al. Among authors: rioja i. Leukemia. 2014 Jan;28(1):88-97. doi: 10.1038/leu.2013.234. Epub 2013 Aug 9. Leukemia. 2014. PMID: 23929215

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Signaling function of PRC2 is essential for TCR-driven T cell responses.

Dobenecker MW, Park JS, Marcello J, McCabe MT, Gregory R, Knight SD, Rioja I, Bassil AK, Prinjha RK, Tarakhovsky A. Dobenecker MW, et al. Among authors: rioja i. J Exp Med. 2018 Apr 2;215(4):1101-1113. doi: 10.1084/jem.20170084. Epub 2018 Mar 9. J Exp Med. 2018. PMID: 29523590 Free PMC article.

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Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment.

Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF. Rioja I, et al. Clin Exp Immunol. 2004 Jul;137(1):65-73. doi: 10.1111/j.1365-2249.2004.02499.x. Clin Exp Immunol. 2004. PMID: 15196245 Free PMC article.

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