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Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.
Metz P, Tjan MJH, Wu S, Pervaiz M, Hermans S, Shettigar A, Sears CL, Ritschel T, Dutilh BE, Boleij A. Metz P, et al. Among authors: ritschel t. Front Cell Infect Microbiol. 2019 Oct 25;9:364. doi: 10.3389/fcimb.2019.00364. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31709196 Free PMC article.
Synthetic polymers as substrates for a DNA-sliding clamp protein.
van Dongen SFM, Clerx J, van den Boomen OI, Pervaiz M, Trakselis MA, Ritschel T, Schoonen L, Schoenmakers DC, Nolte RJM. van Dongen SFM, et al. Among authors: ritschel t. Biopolymers. 2018 May;109(5):e23119. doi: 10.1002/bip.23119. Epub 2018 Apr 26. Biopolymers. 2018. PMID: 29700825 Free PMC article.
Molecular interaction fingerprint approaches for GPCR drug discovery.
Vass M, Kooistra AJ, Ritschel T, Leurs R, de Esch IJ, de Graaf C. Vass M, et al. Among authors: ritschel t. Curr Opin Pharmacol. 2016 Oct;30:59-68. doi: 10.1016/j.coph.2016.07.007. Epub 2016 Jul 29. Curr Opin Pharmacol. 2016. PMID: 27479316 Review.
Discovery of small molecule CD40-TRAF6 inhibitors.
Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA. Zarzycka B, et al. Among authors: ritschel t. J Chem Inf Model. 2015 Feb 23;55(2):294-307. doi: 10.1021/ci500631e. Epub 2015 Jan 27. J Chem Inf Model. 2015. PMID: 25622654
Influence of azide incorporation on binding affinity by small papain inhibitors.
Wammes AE, Hendriks TG, Amatdjais-Groenen HI, Wijdeven MA, van Hest JC, van Delft FL, Ritschel T, Rutjes FP. Wammes AE, et al. Among authors: ritschel t. Bioorg Med Chem. 2014 Oct 15;22(20):5593-603. doi: 10.1016/j.bmc.2014.06.001. Epub 2014 Jun 11. Bioorg Med Chem. 2014. PMID: 24972724
Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.
Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG. Schirris TJ, et al. Among authors: ritschel t. Cell Metab. 2015 Sep 1;22(3):399-407. doi: 10.1016/j.cmet.2015.08.002. Cell Metab. 2015. PMID: 26331605 Free article.
56 results