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Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.
Haaz MC, Rivory L, Riché C, Vernillet L, Robert J. Haaz MC, et al. Cancer Res. 1998 Feb 1;58(3):468-72. Cancer Res. 1998. PMID: 9458091
Irinotecan (CPT-11) is a water-soluble analogue of camptothecin showing activity in colon cancer. Recently, we identified a major metabolite of CPT-11 in patients' plasma, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin (APC), which is produce …
Irinotecan (CPT-11) is a water-soluble analogue of camptothecin showing activity in colon cancer. Recently, we identified a major met …
Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients.
Rivory LP, Riou JF, Haaz MC, Sable S, Vuilhorgne M, Commerçon A, Pond SM, Robert J. Rivory LP, et al. Cancer Res. 1996 Aug 15;56(16):3689-94. Cancer Res. 1996. PMID: 8706009
We have reported previously the presence of an important polar metabolite, in addition to 7-ethyl-10-hydroxycamptothecin (SN-38) beta-glucuronide, in samples of plasma taken from patients undergoing treatment with CPT-11 (L.P. Rivory and J. Robert, Cancer Chemother. …
We have reported previously the presence of an important polar metabolite, in addition to 7-ethyl-10-hydroxycamptothecin (SN-38) beta-glucur …
Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials.
Rivory LP, Haaz MC, Canal P, Lokiec F, Armand JP, Robert J. Rivory LP, et al. Clin Cancer Res. 1997 Aug;3(8):1261-6. Clin Cancer Res. 1997. PMID: 9815808 Clinical Trial.
Recently, we identified an additional metabolite of CPT-11, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin (APC; L. P. Rivory et al. , Cancer Res., 56: 3689-3694, 1996). The aim of this study was to investig …
Recently, we identified an additional metabolite of CPT-11, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin (A …