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RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility.
Shoji T, Takaya A, Sato Y, Kimura S, Suzuki T, Yamamoto T. Shoji T, et al. Nucleic Acids Res. 2015 Oct 15;43(18):8964-72. doi: 10.1093/nar/gkv609. Epub 2015 Sep 13. Nucleic Acids Res. 2015. PMID: 26365244 Free PMC article.
U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmA(II) in vivo, leading to TEL resistance when the nucleotide A2058, …
U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. …
Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD.
Jiang Y, Li F, Wu J, Shi Y, Gong Q. Jiang Y, et al. PLoS One. 2017 Sep 26;12(9):e0185226. doi: 10.1371/journal.pone.0185226. eCollection 2017. PLoS One. 2017. PMID: 28949991 Free PMC article.
Furthermore, structural comparison between RlmCD and its structural homologue RumA, which only catalyzes the m5U1939 in Escherichia coli, implicates that a unique long linker in the central domain of RlmCD is the key factor in determining its substrate selectivity. …
Furthermore, structural comparison between RlmCD and its structural homologue RumA, which only catalyzes the m5U1939 in Escherichia c …
Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD.
Jiang Y, Yu H, Li F, Cheng L, Zhu L, Shi Y, Gong Q. Jiang Y, et al. PLoS Pathog. 2018 Nov 2;14(11):e1007379. doi: 10.1371/journal.ppat.1007379. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30388185 Free PMC article.
Methyltransferase RlmCD was previously shown to be responsible for the introduction of C5 methylation at both U747 and U1939 of the 23S ribosomal RNA in Streptococcus pneumoniae. ...We demonstrate that multiple structural features collaborate to establish the dual enzymati …
Methyltransferase RlmCD was previously shown to be responsible for the introduction of C5 methylation at both U747 and U1939 of the 2 …
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.
Desmolaize B, Fabret C, Brégeon D, Rose S, Grosjean H, Douthwaite S. Desmolaize B, et al. Nucleic Acids Res. 2011 Nov;39(21):9368-75. doi: 10.1093/nar/gkr626. Epub 2011 Aug 8. Nucleic Acids Res. 2011. PMID: 21824914 Free PMC article.
The findings suggest that during evolution, COG2265 enzymes have undergone a series of changes in target specificity and that YefA is closer to an archetypical m(5)U methyltransferase. To reflect its dual specificity, YefA is renamed RlmCD....
The findings suggest that during evolution, COG2265 enzymes have undergone a series of changes in target specificity and that YefA is closer …