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Roadblocks and resolutions in eukaryotic translation.
Schuller AP, Green R. Schuller AP, et al. Nat Rev Mol Cell Biol. 2018 Aug;19(8):526-541. doi: 10.1038/s41580-018-0011-4. Nat Rev Mol Cell Biol. 2018. PMID: 29760421 Free PMC article. Review.
During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are largely determined by substrate availability, amino acid features and reaction kinetics. ...In this Review, we focus on these roadblocks and the resumption of normal t
During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are largely determined by substrate avail …
Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds.
Rousset F, Schmidbauer D, Fink S, Adel Y, Obexer B, Müller M, Glueckert R, Löwenheim H, Senn P. Rousset F, et al. Hear Res. 2022 Feb;414:108391. doi: 10.1016/j.heares.2021.108391. Epub 2021 Nov 14. Hear Res. 2022. PMID: 34844170 Free article.
Auditory neurons connect the sensory hair cells from the inner ear to the brainstem. These bipolar neurons are relevant targets for pharmacological intervention aiming at protecting or improving the hearing function in various forms of sensorineural hearing loss. In the re …
Auditory neurons connect the sensory hair cells from the inner ear to the brainstem. These bipolar neurons are relevant targets for p …
Quantitative analysis of morphogenesis and growth dynamics in an obligate intracellular bacterium.
Figueroa-Cuilan WM, Irazoki O, Feeley M, Smith E, Nguyen T, Cava F, Goley ED. Figueroa-Cuilan WM, et al. Mol Biol Cell. 2023 Jun 1;34(7):ar69. doi: 10.1091/mbc.E23-01-0023. Epub 2023 Apr 5. Mol Biol Cell. 2023. PMID: 37017481 Free PMC article.
We further demonstrated the feasibility of localizing fluorescence fusions, for example, to the cell division protein ZapA, in live R. parkeri for the first time. To evaluate population growth kinetics, we developed an imaging-based assay that improves on the throughput an …
We further demonstrated the feasibility of localizing fluorescence fusions, for example, to the cell division protein ZapA, in live R …
Quantitative imaging for discovery and assembly of the metabo-regulome.
Okumoto S, Takanaga H, Frommer WB. Okumoto S, et al. New Phytol. 2008;180(2):271-295. doi: 10.1111/j.1469-8137.2008.02611.x. New Phytol. 2008. PMID: 19138219 Free PMC article. Review.
The difficulty of measuring metabolites with cellular and subcellular precision is a major roadblock. New tools have been developed for monitoring extracellular, cytosolic, organellar and vacuolar ion and metabolite concentrations with a time resolution of milliseco …
The difficulty of measuring metabolites with cellular and subcellular precision is a major roadblock. New tools have been developed f …
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy.
Bergholt MS, Albro MB, Stevens MM. Bergholt MS, et al. Biomaterials. 2017 Sep;140:128-137. doi: 10.1016/j.biomaterials.2017.06.015. Epub 2017 Jun 14. Biomaterials. 2017. PMID: 28649013 Free PMC article.
Raman spectroscopy, on the other hand, represents a non-invasive technique for in situ biochemical characterization. Here, we outline current roadblocks in translational Raman spectroscopy in TE and introduce a comprehensive workflow designed to non-destructively mo …
Raman spectroscopy, on the other hand, represents a non-invasive technique for in situ biochemical characterization. Here, we outline curren …