Roark WH - Search Results

1

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents.

Roth BD, Blankley CJ, Hoefle ML, Holmes A, Roark WH, Trivedi BK, Essenburg AD, Kieft KA, Krause BR, Stanfield RL. Roth BD, et al. Among authors: roark wh. J Med Chem. 1992 May 1;35(9):1609-17. doi: 10.1021/jm00087a016. J Med Chem. 1992. PMID: 1578488

2

Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.

Sliskovic DR, Blankley CJ, Krause BR, Newton RS, Picard JA, Roark WH, Roth BD, Sekerke C, Shaw MK, Stanfield RL. Sliskovic DR, et al. Among authors: roark wh. J Med Chem. 1992 May 29;35(11):2095-103. doi: 10.1021/jm00089a022. J Med Chem. 1992. PMID: 1597859

3

Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.

Sliskovic DR, Picard JA, Roark WH, Roth BD, Ferguson E, Krause BR, Newton RS, Sekerke C, Shaw MK. Sliskovic DR, et al. Among authors: roark wh. J Med Chem. 1991 Jan;34(1):367-73. doi: 10.1021/jm00105a057. J Med Chem. 1991. PMID: 1992138

4

Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents.

Trivedi BK, Holmes A, Stoeber TL, Blankley CJ, Roark WH, Picard JA, Shaw MK, Essenburg AD, Stanfield RL, Krause BR. Trivedi BK, et al. Among authors: roark wh. J Med Chem. 1993 Oct 29;36(22):3300-7. doi: 10.1021/jm00074a011. J Med Chem. 1993. PMID: 8230120

5

Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond.

Roark WH, Roth BD, Holmes A, Trivedi BK, Kieft KA, Essenburg AD, Krause BR, Stanfield RL. Roark WH, et al. J Med Chem. 1993 May 28;36(11):1662-8. doi: 10.1021/jm00063a016. J Med Chem. 1993. PMID: 8496932

6

Bioisosterism in drug design: identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors.

Roark WH, Padia J, Bolton GL, Blankley CJ, Essenburg AD, Stanfield RL, Bousley RF, Krause BR, Roth BD. Roark WH, et al. Bioorg Med Chem. 1995 Jan;3(1):29-39. doi: 10.1016/0968-0896(94)00144-r. Bioorg Med Chem. 1995. PMID: 8612044

7

alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity.

Sliskovic DR, Picard JA, O'Brien PM, Liao P, Roark WH, Roth BD, Anderson MA, Mueller SB, Bocan TM, Bousley RF, Hamelehle KL, Homan R, Reindel JF, Stanfield RL, Turluck D, Krause BR. Sliskovic DR, et al. Among authors: roark wh. J Med Chem. 1998 Feb 26;41(5):682-90. doi: 10.1021/jm970560h. J Med Chem. 1998. PMID: 9513596

8

Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates.

Lee HT, Roark WH, Picard JA, Sliskovic DR, Roth BD, Stanfield RL, Hamelehle KL, Bousley RF, Krause BR. Lee HT, et al. Among authors: roark wh. Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94. doi: 10.1016/s0960-894x(98)00011-0. Bioorg Med Chem Lett. 1998. PMID: 9871672

9

Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.

Roark WH, Tinney FJ, Cohen D, Essenburg AD, Kaplan HR. Roark WH, et al. J Med Chem. 1985 Sep;28(9):1291-5. doi: 10.1021/jm00147a030. J Med Chem. 1985. PMID: 2993618

10

New inhibitors of human renin that contain novel replacements at the P2 site.

Doherty AM, Kaltenbronn JS, Hudspeth JP, Repine JT, Roark WH, Sircar I, Tinney FJ, Connolly CJ, Hodges JC, Taylor MD, et al. Doherty AM, et al. Among authors: roark wh. J Med Chem. 1991 Apr;34(4):1258-71. doi: 10.1021/jm00108a004. J Med Chem. 1991. PMID: 1901910

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