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Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.
Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG. Lin HM, et al. J Biol Chem. 2009 May 1;284(18):12246-57. doi: 10.1074/jbc.M805379200. Epub 2009 Mar 5. J Biol Chem. 2009. PMID: 19265200 Free PMC article.
RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.
Piek E, Van Dinther M, Parks WT, Sallee JM, Böttinger EP, Roberts AB, Ten Dijke P. Piek E, et al. Biochem J. 2004 Oct 1;383(Pt 1):187-99. doi: 10.1042/BJ20040774. Biochem J. 2004. PMID: 15239668 Free PMC article.
We have described previously the use of microarray technology to identify novel target genes of TGF-beta (transforming growth factor-beta) signalling in mouse embryo fibroblasts deficient in Smad2 or Smad3 [Yang, Piek, Zavadil, Liang, Xie, Heyer, Pavlidis, Kucherlapati, Robert
We have described previously the use of microarray technology to identify novel target genes of TGF-beta (transforming growth factor-beta) s …
Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer.
Stuelten CH, Busch JI, Tang B, Flanders KC, Oshima A, Sutton E, Karpova TS, Roberts AB, Wakefield LM, Niederhuber JE. Stuelten CH, et al. PLoS One. 2010 Mar 23;5(3):e9832. doi: 10.1371/journal.pone.0009832. PLoS One. 2010. PMID: 20352126 Free PMC article.
Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo.
Kamaraju AK, Roberts AB. Kamaraju AK, et al. J Biol Chem. 2005 Jan 14;280(2):1024-36. doi: 10.1074/jbc.M403960200. Epub 2004 Nov 1. J Biol Chem. 2005. PMID: 15520018
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. Xavier S, et al. J Biol Chem. 2004 Apr 9;279(15):15167-76. doi: 10.1074/jbc.M309798200. Epub 2004 Jan 19. J Biol Chem. 2004. PMID: 14732719
Lateral signaling enhances TGF-beta response complexity.
Byfield SD, Roberts AB. Byfield SD, et al. Trends Cell Biol. 2004 Mar;14(3):107-11. doi: 10.1016/j.tcb.2004.01.001. Trends Cell Biol. 2004. PMID: 15055198 Review.
Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.
Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB. Flanders KC, et al. Am J Pathol. 2008 Jul;173(1):68-76. doi: 10.2353/ajpath.2008.070937. Epub 2008 May 23. Am J Pathol. 2008. PMID: 18502822 Free PMC article.
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