Roberts AG - Search Results

1

The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.

Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. Roberts AG, et al. Biochemistry. 2011 Dec 20;50(50):10804-18. doi: 10.1021/bi200924t. Epub 2011 Nov 22. Biochemistry. 2011. PMID: 21992114 Free PMC article.

2

The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria.

Roberts AG, Campbell AP, Atkins WM. Roberts AG, et al. Biochemistry. 2005 Feb 1;44(4):1353-66. doi: 10.1021/bi0481390. Biochemistry. 2005. PMID: 15667229

3

Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4.

Roberts AG, Atkins WM. Roberts AG, et al. Arch Biochem Biophys. 2007 Jul 1;463(1):89-101. doi: 10.1016/j.abb.2007.03.006. Epub 2007 Apr 2. Arch Biochem Biophys. 2007. PMID: 17459328 Free PMC article.

4

Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.

Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Among authors: roberts ag. Biochemistry. 2010 Oct 12;49(40):8709-20. doi: 10.1021/bi100914z. Epub 2010 Sep 15. Biochemistry. 2010. PMID: 20815363 Free PMC article.

5

NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation.

Roberts AG, Sjögren SE, Fomina N, Vu KT, Almutairi A, Halpert JR. Roberts AG, et al. Biochemistry. 2011 Mar 29;50(12):2123-34. doi: 10.1021/bi101797v. Epub 2011 Mar 4. Biochemistry. 2011. PMID: 21375273 Free PMC article.

6

Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.

Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL Jr, Stout CD, Hollenberg PF, Halpert JR. Gay SC, et al. Among authors: roberts ag. Biochemistry. 2011 Jun 7;50(22):4903-11. doi: 10.1021/bi200482g. Epub 2011 May 13. Biochemistry. 2011. PMID: 21510666 Free PMC article.

7

Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry.

Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD. Wen B, et al. Among authors: roberts ag. Biochemistry. 2005 Feb 15;44(6):1833-45. doi: 10.1021/bi048228c. Biochemistry. 2005. PMID: 15697209

8

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

Cameron MD, Wen B, Allen KE, Roberts AG, Schuman JT, Campbell AP, Kunze KL, Nelson SD. Cameron MD, et al. Among authors: roberts ag. Biochemistry. 2005 Nov 1;44(43):14143-51. doi: 10.1021/bi051689t. Biochemistry. 2005. PMID: 16245930

9

NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity.

Roberts AG, Díaz MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP. Roberts AG, et al. Biochemistry. 2006 Feb 14;45(6):1673-84. doi: 10.1021/bi0518895. Biochemistry. 2006. PMID: 16460014

10

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Wen B, et al. Among authors: roberts ag. Arch Biochem Biophys. 2006 Oct 1;454(1):42-54. doi: 10.1016/j.abb.2006.08.003. Epub 2006 Aug 22. Arch Biochem Biophys. 2006. PMID: 16959210 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

157 results

Search Page