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Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A.
Kroetsch AM, Sahin E, Wang HY, Krizman S, Roberts CJ. Kroetsch AM, et al. Among authors: roberts cj. J Pharm Sci. 2012 Oct;101(10):3651-60. doi: 10.1002/jps.23264. Epub 2012 Jul 17. J Pharm Sci. 2012. PMID: 22806414
Visible and subvisible particle formation during the storage of protein solutions is of increasing concern for pharmaceutical products. Previous work (Li Y, Ogunnaike BA, Roberts CJ. 2010. J Pharm Sci 99:645-662) showed that the model protein, alpha-chymotrypsinogen …
Visible and subvisible particle formation during the storage of protein solutions is of increasing concern for pharmaceutical products. Prev …
Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
Sahin E, Jordan JL, Spatara ML, Naranjo A, Costanzo JA, Weiss WF, Robinson AS, Fernandez EJ, Roberts CJ. Sahin E, et al. Among authors: roberts cj. Biochemistry. 2011 Feb 8;50(5):628-39. doi: 10.1021/bi100978r. Epub 2011 Jan 13. Biochemistry. 2011. PMID: 21184609
755 results