Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A.
Kroetsch AM, Sahin E, Wang HY, Krizman S, Roberts CJ.
Kroetsch AM, et al. Among authors: roberts cj.
J Pharm Sci. 2012 Oct;101(10):3651-60. doi: 10.1002/jps.23264. Epub 2012 Jul 17.
J Pharm Sci. 2012.
PMID: 22806414
Visible and subvisible particle formation during the storage of protein solutions is of increasing concern for pharmaceutical products. Previous work (Li Y, Ogunnaike BA, Roberts CJ. 2010. J Pharm Sci 99:645-662) showed that the model protein, alpha-chymotrypsinogen …
Visible and subvisible particle formation during the storage of protein solutions is of increasing concern for pharmaceutical products. Prev …