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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. Lee JS, et al. Nat Med. 2006 Apr;12(4):410-6. doi: 10.1038/nm1377. Epub 2006 Mar 12. Nat Med. 2006. PMID: 16532004
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W. Taniguchi K, et al. Oncogene. 2002 Jul 18;21(31):4863-71. doi: 10.1038/sj.onc.1205591. Oncogene. 2002. PMID: 12101426
Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers.
Ferber MJ, Montoya DP, Yu C, Aderca I, McGee A, Thorland EC, Nagorney DM, Gostout BS, Burgart LJ, Boix L, Bruix J, McMahon BJ, Cheung TH, Chung TK, Wong YF, Smith DI, Roberts LR. Ferber MJ, et al. Oncogene. 2003 Jun 12;22(24):3813-20. doi: 10.1038/sj.onc.1206528. Oncogene. 2003. PMID: 12802289
Parkin gene alterations in hepatocellular carcinoma.
Wang F, Denison S, Lai JP, Philips LA, Montoya D, Kock N, Schüle B, Klein C, Shridhar V, Roberts LR, Smith DI. Wang F, et al. Genes Chromosomes Cancer. 2004 Jun;40(2):85-96. doi: 10.1002/gcc.20020. Genes Chromosomes Cancer. 2004. PMID: 15101042
Emerging drugs for hepatocellular carcinoma.
Roberts LR, Gores GJ. Roberts LR, et al. Expert Opin Emerg Drugs. 2006 Sep;11(3):469-87. doi: 10.1517/14728214.11.3.469. Expert Opin Emerg Drugs. 2006. PMID: 16939386 Review.
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.
Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK, Guerrero RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Shire AM, Nagorney DM, Sanderson SO, Adjei AA, Lee JS, Thorgeirsson SS, Roberts LR. Lai JP, et al. Hepatology. 2008 Apr;47(4):1211-22. doi: 10.1002/hep.22202. Hepatology. 2008. PMID: 18318435 Free PMC article.
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.
Chien J, Narita K, Rattan R, Giri S, Shridhar R, Staub J, Beleford D, Lai J, Roberts LR, Molina J, Kaufmann SH, Prendergast GC, Shridhar V. Chien J, et al. Oncogene. 2008 Dec 11;27(58):7223-34. doi: 10.1038/onc.2008.360. Epub 2008 Sep 22. Oncogene. 2008. PMID: 18806825 Free PMC article.
Treatment options for hepatocellular carcinoma.
Sandhu DS, Tharayil VS, Lai JP, Roberts LR. Sandhu DS, et al. Expert Rev Gastroenterol Hepatol. 2008 Feb;2(1):81-92. doi: 10.1586/17474124.2.1.81. Expert Rev Gastroenterol Hepatol. 2008. PMID: 19072372 Review.
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