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Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy.
Nagueh SF, Chen S, Patel R, Tsybouleva N, Lutucuta S, Kopelen HA, Zoghbi WA, Quiñones MA, Roberts R, Marian AJ. Nagueh SF, et al. J Mol Cell Cardiol. 2004 May;36(5):663-73. doi: 10.1016/j.yjmcc.2004.02.010. J Mol Cell Cardiol. 2004. PMID: 15135661 Free PMC article.
Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy.
Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT, Marian AJ. Osio A, et al. Circ Res. 2007 Mar 30;100(6):766-8. doi: 10.1161/01.RES.0000263008.66799.aa. Epub 2007 Mar 8. Circ Res. 2007. PMID: 17347475 Free PMC article.
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
Patel R, Lim DS, Reddy D, Nagueh SF, Lutucuta S, Sole MJ, Zoghbi WA, Quiñones MA, Roberts R, Marian AJ. Patel R, et al. J Mol Cell Cardiol. 2000 Dec;32(12):2369-77. doi: 10.1006/jmcc.2000.1267. J Mol Cell Cardiol. 2000. PMID: 11113012
On Koch's postulates, causality and genetics of cardiomyopathies.
Marian AJ, Roberts R. Marian AJ, et al. J Mol Cell Cardiol. 2002 Aug;34(8):971-4. doi: 10.1006/jmcc.2002.2048. J Mol Cell Cardiol. 2002. PMID: 12234766 No abstract available.
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.
Patel R, Nagueh SF, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen HA, Quinones MA, Zoghbi WA, Entman ML, Roberts R, Marian AJ. Patel R, et al. Circulation. 2001 Jul 17;104(3):317-24. doi: 10.1161/hc2801.094031. Circulation. 2001. PMID: 11457751 Free PMC article.
Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q(92), responsible for human hypertrophic cardiomyopathy.
Lim DS, Oberst L, McCluggage M, Youker K, Lacy J, DeMayo F, Entman ML, Roberts R, Michael LH, Marian AJ. Lim DS, et al. J Mol Cell Cardiol. 2000 Mar;32(3):365-74. doi: 10.1006/jmcc.1999.1081. J Mol Cell Cardiol. 2000. PMID: 10731436
Transgenes were constructed by placing wild-type (R(92)) or mutant (Q(92)) full-length human cTnT cDNAs 3' into a 5.5-kb murine [alpha -myosin heavy chain (MyHC)] promoter injected into fertilized zygotes. ...
Transgenes were constructed by placing wild-type (R(92)) or mutant (Q(92)) full-length human cTnT cDNAs 3' into a 5.5-kb murine [alph …
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