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The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
Zhang Q, Ragnauth C, Greener MJ, Shanahan CM, Roberts RG. Zhang Q, et al. Among authors: roberts rg. Genomics. 2002 Nov;80(5):473-81. Genomics. 2002. PMID: 12408964
Nesprin-2 epsilon: a novel nesprin isoform expressed in human ovary and Ntera-2 cells.
Lam le T, Böhm SV, Roberts RG, Morris GE. Lam le T, et al. Among authors: roberts rg. Biochem Biophys Res Commun. 2011 Aug 26;412(2):291-5. doi: 10.1016/j.bbrc.2011.07.085. Epub 2011 Jul 28. Biochem Biophys Res Commun. 2011. PMID: 21820406
Structural evolution of the BRCA1 genomic region in primates.
Jin H, Selfe J, Whitehouse C, Morris JR, Solomon E, Roberts RG. Jin H, et al. Among authors: roberts rg. Genomics. 2004 Dec;84(6):1071-82. doi: 10.1016/j.ygeno.2004.08.019. Genomics. 2004. PMID: 15533724
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.
Zhang Q, Ragnauth CD, Skepper JN, Worth NF, Warren DT, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM. Zhang Q, et al. Among authors: roberts rg. J Cell Sci. 2005 Feb 15;118(Pt 4):673-87. doi: 10.1242/jcs.01642. Epub 2005 Jan 25. J Cell Sci. 2005. PMID: 15671068
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.
Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM. Zhang Q, et al. Among authors: roberts rg. Hum Mol Genet. 2007 Dec 1;16(23):2816-33. doi: 10.1093/hmg/ddm238. Epub 2007 Aug 29. Hum Mol Genet. 2007. PMID: 17761684
Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene.
King K, Bagnall R, Fisher SA, Sheikh F, Cuthbert A, Tan S, Mundy NI, Rosenstiel P, Schreiber S, Mathew CG, Roberts RG. King K, et al. Among authors: roberts rg. Genomics. 2007 Oct;90(4):493-501. doi: 10.1016/j.ygeno.2007.07.009. Epub 2007 Aug 24. Genomics. 2007. PMID: 17719742
The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms.
Jin H, Tan S, Hermanowski J, Böhm S, Pacheco S, McCauley JM, Greener MJ, Hinits Y, Hughes SM, Sharpe PT, Roberts RG. Jin H, et al. Among authors: roberts rg. BMC Genomics. 2007 Jan 17;8:19. doi: 10.1186/1471-2164-8-19. BMC Genomics. 2007. PMID: 17233888 Free PMC article.
Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms.
Simpson JG, Roberts RG. Simpson JG, et al. Among authors: roberts rg. Biochem Soc Trans. 2008 Dec;36(Pt 6):1359-67. doi: 10.1042/BST0361359. Biochem Soc Trans. 2008. PMID: 19021556
Conservation of components of the dystrophin complex in Drosophila.
Greener MJ, Roberts RG. Greener MJ, et al. Among authors: roberts rg. FEBS Lett. 2000 Sep 29;482(1-2):13-8. doi: 10.1016/s0014-5793(00)02018-4. FEBS Lett. 2000. PMID: 11018515 Review.
The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins.
Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL. Jin H, et al. Among authors: roberts rg. Genomics. 1999 Nov 1;61(3):259-67. doi: 10.1006/geno.1999.5966. Genomics. 1999. PMID: 10552927
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