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108 results
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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH. Niedernhofer LJ, et al. Among authors: robinson ar. Nature. 2006 Dec 21;444(7122):1038-43. doi: 10.1038/nature05456. Nature. 2006. PMID: 17183314
Delayed and accelerated aging share common longevity assurance mechanisms.
Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Schumacher B, et al. Among authors: robinson ar. PLoS Genet. 2008 Aug 15;4(8):e1000161. doi: 10.1371/journal.pgen.1000161. PLoS Genet. 2008. PMID: 18704162 Free PMC article.
Premature aging-related peripheral neuropathy in a mouse model of progeria.
Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ. Goss JR, et al. Among authors: robinson ar. Mech Ageing Dev. 2011 Aug;132(8-9):437-42. doi: 10.1016/j.mad.2011.04.010. Epub 2011 May 11. Mech Ageing Dev. 2011. PMID: 21596054 Free PMC article.
A mouse model of accelerated liver aging caused by a defect in DNA repair.
Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. Gregg SQ, et al. Among authors: robinson ar. Hepatology. 2012 Feb;55(2):609-21. doi: 10.1002/hep.24713. Hepatology. 2012. PMID: 21953681 Free PMC article.
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
Jaspers NG, Raams A, Silengo MC, Wijgers N, Niedernhofer LJ, Robinson AR, Giglia-Mari G, Hoogstraten D, Kleijer WJ, Hoeijmakers JH, Vermeulen W. Jaspers NG, et al. Among authors: robinson ar. Am J Hum Genet. 2007 Mar;80(3):457-66. doi: 10.1086/512486. Epub 2007 Jan 29. Am J Hum Genet. 2007. PMID: 17273966 Free PMC article.
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Robinson AR, et al. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. Redox Biol. 2018. PMID: 29747066 Free PMC article.
Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.
Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV. Nasto LA, et al. Among authors: robinson ar. Mech Ageing Dev. 2013 Jan-Feb;134(1-2):35-42. doi: 10.1016/j.mad.2012.11.002. Epub 2012 Dec 19. Mech Ageing Dev. 2013. PMID: 23262094 Free PMC article.
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. Tilstra JS, et al. Among authors: robinson ar. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. J Clin Invest. 2012. PMID: 22706308 Free PMC article.
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