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Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).
Rock EM, Parker LA. Rock EM, et al. Behav Neurosci. 2015 Jun;129(3):368-70. doi: 10.1037/bne0000057. Behav Neurosci. 2015. PMID: 26030435
The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.
Rock EM, Limebeer CL, Mechoulam R, Piomelli D, Parker LA. Rock EM, et al. Psychopharmacology (Berl). 2008 Feb;196(3):389-95. doi: 10.1007/s00213-007-0970-1. Epub 2007 Nov 9. Psychopharmacology (Berl). 2008. PMID: 17992520
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
Parker LA, Limebeer CL, Rock EM, Litt DL, Kwiatkowska M, Piomelli D. Parker LA, et al. Among authors: rock em. Physiol Behav. 2009 Apr 20;97(1):121-4. doi: 10.1016/j.physbeh.2009.02.014. Epub 2009 Feb 23. Physiol Behav. 2009. PMID: 19239915 Free PMC article.
Regulation of nausea and vomiting by cannabinoids.
Parker LA, Rock EM, Limebeer CL. Parker LA, et al. Among authors: rock em. Br J Pharmacol. 2011 Aug;163(7):1411-22. doi: 10.1111/j.1476-5381.2010.01176.x. Br J Pharmacol. 2011. PMID: 21175589 Free PMC article. Review.
Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.
Rock EM, Goodwin JM, Limebeer CL, Breuer A, Pertwee RG, Mechoulam R, Parker LA. Rock EM, et al. Psychopharmacology (Berl). 2011 Jun;215(3):505-12. doi: 10.1007/s00213-010-2157-4. Epub 2011 Jan 18. Psychopharmacology (Berl). 2011. PMID: 21243485
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.
Sticht MA, Long JZ, Rock EM, Limebeer CL, Mechoulam R, Cravatt BF, Parker LA. Sticht MA, et al. Among authors: rock em. Br J Pharmacol. 2012 Apr;165(8):2425-35. doi: 10.1111/j.1476-5381.2011.01407.x. Br J Pharmacol. 2012. PMID: 21470205 Free PMC article.
Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA. Rock EM, et al. Br J Pharmacol. 2012 Apr;165(8):2620-34. doi: 10.1111/j.1476-5381.2011.01621.x. Br J Pharmacol. 2012. PMID: 21827451 Free PMC article.
The anti-nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex.
Limebeer CL, Rock EM, Mechoulam R, Parker LA. Limebeer CL, et al. Among authors: rock em. Br J Pharmacol. 2012 Nov;167(5):1126-36. doi: 10.1111/j.1476-5381.2012.02066.x. Br J Pharmacol. 2012. PMID: 22671779 Free PMC article.
Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
O'Brien LD, Wills KL, Segsworth B, Dashney B, Rock EM, Limebeer CL, Parker LA. O'Brien LD, et al. Among authors: rock em. Pharmacol Biochem Behav. 2013 Jan;103(3):597-602. doi: 10.1016/j.pbb.2012.10.008. Epub 2012 Oct 25. Pharmacol Biochem Behav. 2013. PMID: 23103902
Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.
Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG. Bolognini D, et al. Among authors: rock em. Br J Pharmacol. 2013 Mar;168(6):1456-70. doi: 10.1111/bph.12043. Br J Pharmacol. 2013. PMID: 23121618 Free PMC article.
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