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Redesigning trypsin via genetic engineering.
Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. Craik CS, et al. Among authors: roczniak s. J Cell Biochem. 1987 Mar;33(3):199-211. doi: 10.1002/jcb.240330307. J Cell Biochem. 1987. PMID: 3553217 Review. No abstract available.
Redesigning trypsin: alteration of substrate specificity.
Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Craik CS, et al. Among authors: roczniak s. Science. 1985 Apr 19;228(4697):291-7. doi: 10.1126/science.3838593. Science. 1985. PMID: 3838593
Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.
Yung SL, Dela Cruz F, Hamren S, Zhu J, Tsutsumi M, Bloom JW, Caudle M, Roczniak S, Todd T, Lemoine L, MacDougall M, Shanafelt AB, Pan CQ. Yung SL, et al. Among authors: roczniak s. J Biol Chem. 2003 Mar 21;278(12):10273-81. doi: 10.1074/jbc.M211945200. Epub 2003 Jan 13. J Biol Chem. 2003. PMID: 12525492 Free article.
A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo.
Shanafelt AB, Lin Y, Shanafelt MC, Forte CP, Dubois-Stringfellow N, Carter C, Gibbons JA, Cheng SL, Delaria KA, Fleischer R, Greve JM, Gundel R, Harris K, Kelly R, Koh B, Li Y, Lantz L, Mak P, Neyer L, Plym MJ, Roczniak S, Serban D, Thrift J, Tsuchiyama L, Wetzel M, Wong M, Zolotorev A. Shanafelt AB, et al. Among authors: roczniak s. Nat Biotechnol. 2000 Nov;18(11):1197-202. doi: 10.1038/81199. Nat Biotechnol. 2000. PMID: 11062441
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