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Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome.
Rzepecka J, Pineda MA, Al-Riyami L, Rodgers DT, Huggan JK, Lumb FE, Khalaf AI, Meakin PJ, Corbet M, Ashford ML, Suckling CJ, Harnett MM, Harnett W. Rzepecka J, et al. Among authors: rodgers dt. J Autoimmun. 2015 Jun;60:59-73. doi: 10.1016/j.jaut.2015.04.005. Epub 2015 May 11. J Autoimmun. 2015. PMID: 25975491 Free PMC article.
Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.
Al-Riyami L, Pineda MA, Rzepecka J, Huggan JK, Khalaf AI, Suckling CJ, Scott FJ, Rodgers DT, Harnett MM, Harnett W. Al-Riyami L, et al. Among authors: rodgers dt. J Med Chem. 2013 Dec 27;56(24):9982-10002. doi: 10.1021/jm401251p. Epub 2013 Nov 25. J Med Chem. 2013. PMID: 24228757 Free PMC article.
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