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Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
Mellado M, Rodríguez-Frade JM, Mañes S, Martínez-A C. Mellado M, et al. Annu Rev Immunol. 2001;19:397-421. doi: 10.1146/annurev.immunol.19.1.397. Annu Rev Immunol. 2001. PMID: 11244042 Review.
Conformational changes required in the human growth hormone receptor for growth hormone signaling.
Mellado M, Rodríguez-Frade JM, Kremer L, von Kobbe C, de Ana AM, Mérida I, Martinez-A C. Mellado M, et al. J Biol Chem. 1997 Apr 4;272(14):9189-96. doi: 10.1074/jbc.272.14.9189. J Biol Chem. 1997. PMID: 9083050
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
Mellado M, Rodríguez-Frade JM, Aragay A, del Real G, Martín AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martínez-A C. Mellado M, et al. J Immunol. 1998 Jul 15;161(2):805-13. J Immunol. 1998. PMID: 9670957
Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis.
Rodríguez-Frade JM, Vila-Coro AJ, Martín A, Nieto M, Sánchez-Madrid F, Proudfoot AE, Wells TN, Martínez-A C, Mellado M. Rodríguez-Frade JM, et al. J Cell Biol. 1999 Feb 22;144(4):755-65. doi: 10.1083/jcb.144.4.755. J Cell Biol. 1999. PMID: 10037796 Free PMC article.
The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2.
Rodríguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martínez-A C, Mellado M. Rodríguez-Frade JM, et al. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3628-33. doi: 10.1073/pnas.96.7.3628. Proc Natl Acad Sci U S A. 1999. PMID: 10097088 Free PMC article.
Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex.
Vila-Coro AJ, Mellado M, Martín de Ana A, Martínez-A C, Rodríguez-Frade JM. Vila-Coro AJ, et al. J Immunol. 1999 Sep 15;163(6):3037-44. J Immunol. 1999. PMID: 10477567
Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.
Vicente-Manzanares M, Rey M, Jones DR, Sancho D, Mellado M, Rodriguez-Frade JM, del Pozo MA, Yáñez-Mó M, de Ana AM, Martínez-A C, Mérida I, Sánchez-Madrid F. Vicente-Manzanares M, et al. J Immunol. 1999 Oct 1;163(7):4001-12. J Immunol. 1999. PMID: 10491003
The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.
Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, Moreno-Ortíz MC, Martínez-A C, Mellado M. Vila-Coro AJ, et al. FASEB J. 1999 Oct;13(13):1699-710. FASEB J. 1999. PMID: 10506573
HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization.
Vila-Coro AJ, Mellado M, Martín de Ana A, Lucas P, del Real G, Martínez-A C, Rodríguez-Frade JM. Vila-Coro AJ, et al. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3388-93. doi: 10.1073/pnas.050457797. Proc Natl Acad Sci U S A. 2000. PMID: 10725362 Free PMC article.
Role of the PI3K regulatory subunit in the control of actin organization and cell migration.
Jiménez C, Portela RA, Mellado M, Rodríguez-Frade JM, Collard J, Serrano A, Martínez-A C, Avila J, Carrera AC. Jiménez C, et al. J Cell Biol. 2000 Oct 16;151(2):249-62. doi: 10.1083/jcb.151.2.249. J Cell Biol. 2000. PMID: 11038173 Free PMC article.
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