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The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells.
Ramos-Torres Á, Bort A, Morell C, Rodríguez-Henche N, Díaz-Laviada I. Ramos-Torres Á, et al. Among authors: rodriguez henche n. Oncotarget. 2016 Jan 12;7(2):1569-83. doi: 10.18632/oncotarget.6415. Oncotarget. 2016. PMID: 26625315 Free PMC article.
Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation.
Bort A, Spínola E, Rodríguez-Henche N, Díaz-Laviada I. Bort A, et al. Among authors: rodriguez henche n. Oncotarget. 2017 Sep 23;8(50):87684-87698. doi: 10.18632/oncotarget.21196. eCollection 2017 Oct 20. Oncotarget. 2017. PMID: 29152112 Free PMC article.
The potential antitumor effects of capsaicin.
Díaz-Laviada I, Rodríguez-Henche N. Díaz-Laviada I, et al. Prog Drug Res. 2014;68:181-208. doi: 10.1007/978-3-0348-0828-6_8. Prog Drug Res. 2014. PMID: 24941670 Review.
Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation.
Bort A, Sánchez BG, Mateos-Gómez PA, Díaz-Laviada I, Rodríguez-Henche N. Bort A, et al. Among authors: rodriguez henche n. Int J Mol Sci. 2019 Apr 3;20(7):1660. doi: 10.3390/ijms20071660. Int J Mol Sci. 2019. PMID: 30987128 Free PMC article.
Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K.
Gutiérrez-Cañas I, Juarranz MG, Collado B, Rodríguez-Henche N, Chiloeches A, Prieto JC, Carmena MJ. Gutiérrez-Cañas I, et al. Prostate. 2005 Apr 1;63(1):44-55. doi: 10.1002/pros.20173. Prostate. 2005. PMID: 15468165
Vasoactive intestinal peptide increases vascular endothelial growth factor expression and neuroendocrine differentiation in human prostate cancer LNCaP cells.
Collado B, Gutiérrez-Cañas I, Rodríguez-Henche N, Prieto JC, Carmena MJ. Collado B, et al. Regul Pept. 2004 Jun 15;119(1-2):69-75. doi: 10.1016/j.regpep.2004.01.013. Regul Pept. 2004. PMID: 15093699
VIP and PACAP are autocrine factors that protect the androgen-independent prostate cancer cell line PC-3 from apoptosis induced by serum withdrawal.
Gutiérrez-Cañas I, Rodríguez-Henche N, Bolaños O, Carmena MJ, Prieto JC, Juarranz MG. Gutiérrez-Cañas I, et al. Br J Pharmacol. 2003 Jul;139(5):1050-8. doi: 10.1038/sj.bjp.0705317. Br J Pharmacol. 2003. PMID: 12839880 Free PMC article.
The red pepper's spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ.
Bort A, Sánchez BG, Spínola E, Mateos-Gómez PA, Rodríguez-Henche N, Díaz-Laviada I. Bort A, et al. Among authors: rodriguez henche n. PLoS One. 2019 Jan 29;14(1):e0211420. doi: 10.1371/journal.pone.0211420. eCollection 2019. PLoS One. 2019. PMID: 30695053 Free PMC article.
Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase.
Sánchez BG, Bort A, Mateos-Gómez PA, Rodríguez-Henche N, Díaz-Laviada I. Sánchez BG, et al. Among authors: rodriguez henche n. Cancer Cell Int. 2019 Mar 8;19:54. doi: 10.1186/s12935-019-0769-2. eCollection 2019. Cancer Cell Int. 2019. PMID: 30899201 Free PMC article.
Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation.
Bort A, Quesada S, Ramos-Torres Á, Gargantilla M, Priego EM, Raynal S, Lepifre F, Gasalla JM, Rodriguez-Henche N, Castro A, Díaz-Laviada I. Bort A, et al. Among authors: rodriguez henche n. Sci Rep. 2018 Mar 12;8(1):4370. doi: 10.1038/s41598-018-22690-2. Sci Rep. 2018. PMID: 29531259 Free PMC article.
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