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Global analysis of fungal morphology exposes mechanisms of host cell escape.
O'Meara TR, Veri AO, Ketela T, Jiang B, Roemer T, Cowen LE. O'Meara TR, et al. Nat Commun. 2015 Mar 31;6:6741. doi: 10.1038/ncomms7741. Nat Commun. 2015. PMID: 25824284 Free PMC article.
Large-scale analysis of the yeast genome by transposon tagging and gene disruption.
Ross-Macdonald P, Coelho PS, Roemer T, Agarwal S, Kumar A, Jansen R, Cheung KH, Sheehan A, Symoniatis D, Umansky L, Heidtman M, Nelson FK, Iwasaki H, Hager K, Gerstein M, Miller P, Roeder GS, Snyder M. Ross-Macdonald P, et al. Nature. 1999 Nov 25;402(6760):413-8. doi: 10.1038/46558. Nature. 1999. PMID: 10586881
Neutralization of Pathogenic Fungi with Small-Molecule Immunotherapeutics.
Chirkin E, Muthusamy V, Mann P, Roemer T, Nantermet PG, Spiegel DA. Chirkin E, et al. Among authors: roemer t. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13036-13040. doi: 10.1002/anie.201707536. Epub 2017 Sep 11. Angew Chem Int Ed Engl. 2017. PMID: 28793176
Selective small-molecule inhibition of an RNA structural element.
Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753
Bugs, drugs and chemical genomics.
Roemer T, Davies J, Giaever G, Nislow C. Roemer T, et al. Nat Chem Biol. 2011 Dec 15;8(1):46-56. doi: 10.1038/nchembio.744. Nat Chem Biol. 2011. PMID: 22173359 Review.
Systems-level antimicrobial drug and drug synergy discovery.
Roemer T, Boone C. Roemer T, et al. Nat Chem Biol. 2013 Apr;9(4):222-31. doi: 10.1038/nchembio.1205. Nat Chem Biol. 2013. PMID: 23508188
High-frequency transposition for determining antibacterial mode of action.
Wang H, Claveau D, Vaillancourt JP, Roemer T, Meredith TC. Wang H, et al. Nat Chem Biol. 2011 Sep 4;7(10):720-9. doi: 10.1038/nchembio.643. Nat Chem Biol. 2011. PMID: 21892185
Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.
Trunk K, Gendron P, Nantel A, Lemieux S, Roemer T, Raymond M. Trunk K, et al. Eukaryot Cell. 2009 May;8(5):756-67. doi: 10.1128/EC.00332-08. Epub 2009 Mar 6. Eukaryot Cell. 2009. PMID: 19270112 Free PMC article.
Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.
Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, Davison J, Sillaots S, Trosok S, Bachewich C, Bussey H, Youngman P, Roemer T. Xu D, et al. PLoS Pathog. 2007 Jun;3(6):e92. doi: 10.1371/journal.ppat.0030092. PLoS Pathog. 2007. PMID: 17604452 Free PMC article.
Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.
Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T. Mann PA, et al. ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12. ACS Infect Dis. 2015. PMID: 26878058 Free PMC article.
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