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Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M. Roeschert I, et al. Nat Cancer. 2021 Mar;2(3):312-326. doi: 10.1038/s43018-020-00171-8. Epub 2021 Feb 11. Nat Cancer. 2021. PMID: 33768209 Free PMC article.
Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Silveira Vidal R, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Cossa G, et al. Among authors: roeschert i. Mol Cell. 2020 Mar 19;77(6):1322-1339.e11. doi: 10.1016/j.molcel.2020.01.008. Epub 2020 Jan 31. Mol Cell. 2020. PMID: 32006464 Free PMC article.
Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.
Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M. Büchel G, et al. Among authors: roeschert i. Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090. Cell Rep. 2017. PMID: 29262328 Free PMC article.
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal RS, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Kumar A, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Cossa G, et al. Among authors: roeschert i. Mol Cell. 2021 Jun 3;81(11):2495. doi: 10.1016/j.molcel.2021.05.013. Mol Cell. 2021. PMID: 34087181 Free PMC article. No abstract available.