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Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Kenwood BM, et al. Among authors: rogers gw. Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634817 Free PMC article.
SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.
Figarola JL, Singhal J, Tompkins JD, Rogers GW, Warden C, Horne D, Riggs AD, Awasthi S, Singhal SS. Figarola JL, et al. Among authors: rogers gw. J Biol Chem. 2015 Dec 18;290(51):30321-41. doi: 10.1074/jbc.M115.686352. Epub 2015 Nov 3. J Biol Chem. 2015. PMID: 26534958 Free PMC article.
Bioenergetic profile experiment using C2C12 myoblast cells.
Nicholls DG, Darley-Usmar VM, Wu M, Jensen PB, Rogers GW, Ferrick DA. Nicholls DG, et al. Among authors: rogers gw. J Vis Exp. 2010 Dec 6;(46):2511. doi: 10.3791/2511. J Vis Exp. 2010. PMID: 21189469 Free PMC article.
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.
Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. Divakaruni AS, et al. Among authors: rogers gw. Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28. Cell Metab. 2018. PMID: 30043752 Free PMC article.
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