Development and virtual screening of target libraries

Didier Rognan

doi:10.1016/j.jphysparis.2005.12.084

Development and virtual screening of target libraries

J Physiol Paris. 2006 Mar-May;99(2-3):232-44. doi: 10.1016/j.jphysparis.2005.12.084. Epub 2006 Feb 3.

Author

Didier Rognan¹

Affiliation

¹ Bioinformatics of the Drug, CNRS, UMR 7175, 74 route du Rhin, F-67400 Illkirch, France. didier.rognan@pharma.u-strasbg.fr

PMID: 16459061
DOI: 10.1016/j.jphysparis.2005.12.084

Abstract

The concomitant development of in silico screening technologies and of three-dimensional information on therapeutically relevant macromolecular targets makes it possible to navigate in the structural proteome and to identify targets fulfilling user-defined queries. This review illustrates some in-house recent advances in the development of target libraries and how they can be browsed to unravel chemogenomic information.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Combinatorial Chemistry Techniques / methods*
Computer Simulation
Drug Design*
Drug Evaluation, Preclinical
Humans
Ligands
Models, Molecular
Molecular Structure
Peptide Library*
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / metabolism
Structure-Activity Relationship

Substances

Ligands
Peptide Library
Receptors, G-Protein-Coupled