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Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T. Majer P, et al. Among authors: rojas c. J Med Chem. 2003 May 8;46(10):1989-96. doi: 10.1021/jm020515w. J Med Chem. 2003. PMID: 12723961
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Ghadge GD, et al. Among authors: rojas c. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. doi: 10.1073/pnas.1530168100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876198 Free PMC article.
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