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Decreased phenylalanine uptake and turnover in patients with vitiligo.
Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM. Schallreuter KU, et al. Among authors: rokos h. Mol Genet Metab. 2005 Dec;86 Suppl 1:S27-33. doi: 10.1016/j.ymgme.2005.07.023. Epub 2005 Sep 6. Mol Genet Metab. 2005. PMID: 16143555 Review.
Moreover, UVB irradiation (1 MED) significantly increases epidermal PAH activities 24 h after exposure. Importantly, L-phenylalanine uptake and turnover in the pigment forming melanocytes is vital for initiation of melanogenesis. ...
Moreover, UVB irradiation (1 MED) significantly increases epidermal PAH activities 24 h after exposure. Importantly, L-phenylalanine …
Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells.
Schallreuter KU, Hasse S, Rokos H, Chavan B, Shalbaf M, Spencer JD, Wood JM. Schallreuter KU, et al. Among authors: rokos h. Exp Dermatol. 2009 Aug;18(8):680-8. doi: 10.1111/j.1600-0625.2009.00850.x. Epub 2009 Mar 7. Exp Dermatol. 2009. PMID: 19469904
Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo.
Schallreuter KU, Rübsam K, Gibbons NC, Maitland DJ, Chavan B, Zothner C, Rokos H, Wood JM. Schallreuter KU, et al. Among authors: rokos h. J Invest Dermatol. 2008 Apr;128(4):808-15. doi: 10.1038/sj.jid.5701100. Epub 2007 Oct 18. J Invest Dermatol. 2008. PMID: 17943184 Free article.
Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2): potential and pitfalls.
Gibbons NC, Wood JM, Rokos H, Schallreuter KU. Gibbons NC, et al. Among authors: rokos h. J Invest Dermatol. 2006 Dec;126(12):2576-82. doi: 10.1038/sj.jid.5700612. J Invest Dermatol. 2006. PMID: 17108904 Review.
Here we used examples of important epidermal antioxidant enzymes before and after hydrogen peroxide (H(2)O(2))-mediated oxidation of susceptible amino-acid residues (i.e. tryptophan, methionine, cysteine, and selenocysteine), which can affect enzyme active sites, cofactor …
Here we used examples of important epidermal antioxidant enzymes before and after hydrogen peroxide (H(2)O(2))-mediated oxidation of …
A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin.
Spencer JD, Chavan B, Marles LK, Kauser S, Rokos H, Schallreuter KU. Spencer JD, et al. Among authors: rokos h. J Endocrinol. 2005 Nov;187(2):293-302. doi: 10.1677/joe.1.06275. J Endocrinol. 2005. PMID: 16293777
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes.
Chavan B, Gillbro JM, Rokos H, Schallreuter KU. Chavan B, et al. Among authors: rokos h. J Invest Dermatol. 2006 Nov;126(11):2481-9. doi: 10.1038/sj.jid.5700425. Epub 2006 Jun 15. J Invest Dermatol. 2006. PMID: 16778797
Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo.
Schallreuter KU, Chiuchiarelli G, Cemeli E, Elwary SM, Gillbro JM, Spencer JD, Rokos H, Panske A, Chavan B, Wood JM, Anderson D. Schallreuter KU, et al. Among authors: rokos h. J Invest Dermatol. 2006 May;126(5):1036-42. doi: 10.1038/sj.jid.5700257. J Invest Dermatol. 2006. PMID: 16528352
Recently, the generation of H(2)O(2) by oxidative metabolism of estrogens and other aromatic steroids was documented. Therefore, it was tempting to follow estrogen-generated H(2)O(2) and its possible effect on DNA damage in peripheral blood lymphocytes from patients …
Recently, the generation of H(2)O(2) by oxidative metabolism of estrogens and other aromatic steroids was documented. Therefore, it w …
Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo.
Spencer JD, Gibbons NC, Rokos H, Peters EM, Wood JM, Schallreuter KU. Spencer JD, et al. Among authors: rokos h. J Invest Dermatol. 2007 Feb;127(2):411-20. doi: 10.1038/sj.jid.5700538. Epub 2006 Aug 31. J Invest Dermatol. 2007. PMID: 16946714
The redox--biochemistry of human hair pigmentation.
Schallreuter KU, Salem MM, Hasse S, Rokos H. Schallreuter KU, et al. Among authors: rokos h. Pigment Cell Melanoma Res. 2011 Feb;24(1):51-62. doi: 10.1111/j.1755-148X.2010.00794.x. Epub 2010 Dec 1. Pigment Cell Melanoma Res. 2011. PMID: 20958953
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels.
Schallreuter KU, Salem MA, Gibbons NC, Martinez A, Slominski R, Lüdemann J, Rokos H. Schallreuter KU, et al. Among authors: rokos h. FASEB J. 2012 Jun;26(6):2457-70. doi: 10.1096/fj.11-197137. Epub 2012 Mar 13. FASEB J. 2012. PMID: 22415302
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