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Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.
Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA. Takeda K, et al. J Biol Chem. 2007 Apr 20;282(16):11874-84. doi: 10.1074/jbc.M610984200. Epub 2007 Mar 1. J Biol Chem. 2007. PMID: 17331950 Free article.
We took a systematic approach to characterize the functions of the six putative Class I phosphatidylinositol 3-kinases (PI3K1-6) in Dictyostelium by creating a series of gene knockouts. These studies revealed that PI3K1-PI3K3 are the major PI3Ks for ch …
We took a systematic approach to characterize the functions of the six putative Class I phosphatidylinositol 3-kinases
Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.
van Haastert PJ, Keizer-Gunnink I, Kortholt A. van Haastert PJ, et al. J Cell Biol. 2007 Jun 4;177(5):809-16. doi: 10.1083/jcb.200701134. Epub 2007 May 29. J Cell Biol. 2007. PMID: 17535967 Free PMC article.
The results show that inhibition of either PI3-kinase or PLA2 inhibits chemotaxis in shallow cAMP gradients, whereas both enzymes must be inhibited to prevent chemotaxis in steep cAMP gradients, suggesting that PI3-kinase and PLA2 are two redundant med …
The results show that inhibition of either PI3-kinase or PLA2 inhibits chemotaxis in shallow cAMP gradients, whereas both enzy …
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.
Han JW, Leeper L, Rivero F, Chung CY. Han JW, et al. J Biol Chem. 2006 Nov 17;281(46):35224-34. doi: 10.1074/jbc.M605997200. Epub 2006 Sep 12. J Biol Chem. 2006. PMID: 16968699 Free PMC article.
Cells overexpressing RacC exhibit a significant increase in the level of F-actin polymerization upon cAMP stimulation, which can be blocked by a phosphatidylinositol (PI) 3-kinase inhibitor. Membrane translocation of PI 3-kinase and PI 3,4,5-trisphosph …
Cells overexpressing RacC exhibit a significant increase in the level of F-actin polymerization upon cAMP stimulation, which can be blocked …
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase.
Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, van Haastert PJ. Loovers HM, et al. Mol Biol Cell. 2006 Apr;17(4):1503-13. doi: 10.1091/mbc.e05-09-0825. Epub 2006 Jan 18. Mol Biol Cell. 2006. PMID: 16421252 Free PMC article.
The role of PI(3,4,5)P(3) in Dictyostelium signal transduction and chemotaxis was investigated using the PI3-kinase inhibitor LY294002 and pi3k-null cells. ...In control cells, PHcrac-GFP and F-actin colocalize upon cAMP stimulation. Howe …
The role of PI(3,4,5)P(3) in Dictyostelium signal transduction and chemotaxis was investigated using the …
Phosphoinositides in chemotaxis.
Weiger MC, Parent CA. Weiger MC, et al. Subcell Biochem. 2012;59:217-54. doi: 10.1007/978-94-007-3015-1_7. Subcell Biochem. 2012. PMID: 22374092 Review.
Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array of biological responses. ...Indeed, parallel signal transduction pathways have been shown to coordinately regulate cell polarity and directe
Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.
Funamoto S, Milan K, Meili R, Firtel RA. Funamoto S, et al. J Cell Biol. 2001 May 14;153(4):795-810. doi: 10.1083/jcb.153.4.795. J Cell Biol. 2001. PMID: 11352940 Free PMC article.
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3' kinases (PI3K and pi3k1/2-null cells) or wild-type cells treated with the PI3K inhibitor LY294002 are unable to properly polarize, are very defective in the temporal, spa …
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3' kinases (PI3K and pi3k1/2-null …
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.
Sasaki AT, Firtel RA. Sasaki AT, et al. Eur J Cell Biol. 2006 Sep;85(9-10):873-95. doi: 10.1016/j.ejcb.2006.04.007. Epub 2006 Jun 5. Eur J Cell Biol. 2006. PMID: 16740339 Free article. Review.
Almost every signaling molecule requires several regulatory processes to be functionally activated, and a lack of a signaling molecule often leads to chemotaxis defects, suggesting an integral role for each component in the pathway. ...Deregulation of those pathways …
Almost every signaling molecule requires several regulatory processes to be functionally activated, and a lack of a signaling molecule often …
Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
Liao XH, Buggey J, Kimmel AR. Liao XH, et al. J Cell Sci. 2010 Mar 15;123(Pt 6):983-92. doi: 10.1242/jcs.064022. J Cell Sci. 2010. PMID: 20200230 Free PMC article.
Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. ...This defines a separate input for signaling in control of chemotaxis and dependency on PDK1 function. We also demonstrate that PDK1 in Dictyostelium functio …
Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. ...This defines a separate input …
The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients.
Firtel RA, Chung CY. Firtel RA, et al. Bioessays. 2000 Jul;22(7):603-15. doi: 10.1002/1521-1878(200007)22:7<603::AID-BIES3>3.0.CO;2-#. Bioessays. 2000. PMID: 10878573 Review.
Chemotaxis plays a central role in various biological processes, such as the movement of neutrophils and macrophage during wound healing and in the aggregation of Dictyostelium cells. During the past few years, new understanding of the mechanisms controlling
Chemotaxis plays a central role in various biological processes, such as the movement of neutrophils and macrophage during wou
PIP3-dependent macropinocytosis is incompatible with chemotaxis.
Veltman DM, Lemieux MG, Knecht DA, Insall RH. Veltman DM, et al. J Cell Biol. 2014 Feb 17;204(4):497-505. doi: 10.1083/jcb.201309081. J Cell Biol. 2014. PMID: 24535823 Free PMC article.
The role of the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) has been particularly controversial. ...Wild-type cells, unlike the widely used axenic mutants, show little macropinocytosis and few large PIP3 patches, but migrate more efficiently toward …
The role of the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) has been particularly controversial. ...Wild-type …
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