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Year Number of Results
2000 2
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Page 1
Phosphatidylinositol 3-kinases play a suppressive role in cell motility of vegetative Dictyostelium cells.
Kim W, Jeon TJ. Kim W, et al. Biochem Biophys Res Commun. 2022 Nov 12;629:106-111. doi: 10.1016/j.bbrc.2022.09.024. Epub 2022 Sep 10. Biochem Biophys Res Commun. 2022. PMID: 36116372
Phosphatidylinositol 3-Kinase (PI3K) is a key regulator of cell motility during chemotaxis and plays an important role in relaying and amplifying the shallow gradient of chemoattractant signals to ultimately mediate rearrangements of the actin cytoskel …
Phosphatidylinositol 3-Kinase (PI3K) is a key regulator of cell motility during chemotaxis and plays an important ro …
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.
Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA. Takeda K, et al. J Biol Chem. 2007 Apr 20;282(16):11874-84. doi: 10.1074/jbc.M610984200. Epub 2007 Mar 1. J Biol Chem. 2007. PMID: 17331950 Free article.
We took a systematic approach to characterize the functions of the six putative Class I phosphatidylinositol 3-kinases (PI3K1-6) in Dictyostelium by creating a series of gene knockouts. These studies revealed that PI3K1-PI3K3 are the major PI3Ks for ch …
We took a systematic approach to characterize the functions of the six putative Class I phosphatidylinositol 3-kinases …
Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.
van Haastert PJ, Keizer-Gunnink I, Kortholt A. van Haastert PJ, et al. J Cell Biol. 2007 Jun 4;177(5):809-16. doi: 10.1083/jcb.200701134. Epub 2007 May 29. J Cell Biol. 2007. PMID: 17535967 Free PMC article.
The results show that inhibition of either PI3-kinase or PLA2 inhibits chemotaxis in shallow cAMP gradients, whereas both enzymes must be inhibited to prevent chemotaxis in steep cAMP gradients, suggesting that PI3-kinase and PLA2 are two redundant med …
The results show that inhibition of either PI3-kinase or PLA2 inhibits chemotaxis in shallow cAMP gradients, whereas both enzy …
Phosphoinositides in chemotaxis.
Weiger MC, Parent CA. Weiger MC, et al. Subcell Biochem. 2012;59:217-54. doi: 10.1007/978-94-007-3015-1_7. Subcell Biochem. 2012. PMID: 22374092 Review.
Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array of biological responses. ...Indeed, parallel signal transduction pathways have been shown to coordinately regulate cell polarity and directe …
Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array …
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.
Han JW, Leeper L, Rivero F, Chung CY. Han JW, et al. J Biol Chem. 2006 Nov 17;281(46):35224-34. doi: 10.1074/jbc.M605997200. Epub 2006 Sep 12. J Biol Chem. 2006. PMID: 16968699 Free PMC article.
Cells overexpressing RacC exhibit a significant increase in the level of F-actin polymerization upon cAMP stimulation, which can be blocked by a phosphatidylinositol (PI) 3-kinase inhibitor. Membrane translocation of PI 3-kinase and PI 3,4,5-trisphosph …
Cells overexpressing RacC exhibit a significant increase in the level of F-actin polymerization upon cAMP stimulation, which can be blocked …
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.
Sasaki AT, Firtel RA. Sasaki AT, et al. Eur J Cell Biol. 2006 Sep;85(9-10):873-95. doi: 10.1016/j.ejcb.2006.04.007. Epub 2006 Jun 5. Eur J Cell Biol. 2006. PMID: 16740339 Review.
Almost every signaling molecule requires several regulatory processes to be functionally activated, and a lack of a signaling molecule often leads to chemotaxis defects, suggesting an integral role for each component in the pathway. ...Deregulation of those pathways …
Almost every signaling molecule requires several regulatory processes to be functionally activated, and a lack of a signaling molecule often …
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase.
Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, van Haastert PJ. Loovers HM, et al. Mol Biol Cell. 2006 Apr;17(4):1503-13. doi: 10.1091/mbc.e05-09-0825. Epub 2006 Jan 18. Mol Biol Cell. 2006. PMID: 16421252 Free PMC article.
The role of PI(3,4,5)P(3) in Dictyostelium signal transduction and chemotaxis was investigated using the PI3-kinase inhibitor LY294002 and pi3k-null cells. ...In control cells, PHcrac-GFP and F-actin colocalize upon cAMP stimulation. Howe …
The role of PI(3,4,5)P(3) in Dictyostelium signal transduction and chemotaxis was investigated using the …
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.
Funamoto S, Milan K, Meili R, Firtel RA. Funamoto S, et al. J Cell Biol. 2001 May 14;153(4):795-810. doi: 10.1083/jcb.153.4.795. J Cell Biol. 2001. PMID: 11352940 Free PMC article.
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3' kinases (PI3K and pi3k1/2-null cells) or wild-type cells treated with the PI3K inhibitor LY294002 are unable to properly polarize, are very defective in the temporal, spa …
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3' kinases (PI3K and pi3k1/2-null …
The regulation of cell motility and chemotaxis by phospholipid signaling.
Kölsch V, Charest PG, Firtel RA. Kölsch V, et al. J Cell Sci. 2008 Mar 1;121(Pt 5):551-9. doi: 10.1242/jcs.023333. J Cell Sci. 2008. PMID: 18287584 Free PMC article. Review.
Phosphoinositide 3-kinase (PI3K), PTEN and localized phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] play key roles in chemotaxis, regulating cell motility by controlling the actin cytoskeleton in Dictyostelium and mammalian …
Phosphoinositide 3-kinase (PI3K), PTEN and localized phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3 …
Spatial regulation of PI3K signaling during chemotaxis.
Iglesias PA. Iglesias PA. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):247-253. doi: 10.1002/wsbm.13. Wiley Interdiscip Rev Syst Biol Med. 2009. PMID: 20835994 Review.
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3' OH position of the inositol ring of phosphoinositides on the inner leaf of the plasma membrane. Receptor-mediated activation of the PI3K pathway plays a crucial …
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3' OH position of the in …
33 results