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Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries.
Cogolludo A, Frazziano G, Cobeño L, Moreno L, Lodi F, Villamor E, Tamargo J, Perez-Vizcaino F. Cogolludo A, et al. Ann N Y Acad Sci. 2006 Dec;1091:41-51. doi: 10.1196/annals.1378.053. Ann N Y Acad Sci. 2006. PMID: 17341601
We have reported that the TXA(2) analog U46619, via activation of TP receptors and PKCzeta, inhibited Kv currents in rat pulmonary artery smooth muscle cells (PASMC), increased cytosolic calcium, and induced a contrac …
We have reported that the TXA(2) analog U46619, via activation of TP receptors and PKCzeta, inhibited Kv
Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta.
Cogolludo A, Moreno L, Bosca L, Tamargo J, Perez-Vizcaino F. Cogolludo A, et al. Circ Res. 2003 Oct 3;93(7):656-63. doi: 10.1161/01.RES.0000095245.97945.FE. Epub 2003 Sep 11. Circ Res. 2003. PMID: 12970114 Free article.
The TXA2 analogue U46619 inhibited IK(V) (Emax=56.1+/-3.9%, EC50=0.054+/-0.019 micromol/L) and depolarized pulmonary artery smooth muscle cells via activation of TP receptors. ...We propose PKCzeta as a link between TP receptor
The TXA2 analogue U46619 inhibited IK(V) (Emax=56.1+/-3.9%, EC50=0.054+/-0.019 micromol/L) and depolarized pulmonary artery