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Role of galectins in inflammatory and immunomodulatory processes.
Rabinovich GA, Rubinstein N, Toscano MA. Rabinovich GA, et al. Biochim Biophys Acta. 2002 Sep 19;1572(2-3):274-84. doi: 10.1016/s0304-4165(02)00314-8. Biochim Biophys Acta. 2002. PMID: 12223275 Review.
These biological effects attracted attention of researchers in cell biology, biochemistry, glycobiology and immunology, not only in the mode of action of galectins, but also in their role as putative modulators of immune surveillance, apoptosis, cell adhesion and ch …
These biological effects attracted attention of researchers in cell biology, biochemistry, glycobiology and immunology, not only in the mode …
Regulation of M1-type and M2-type macrophage polarization in RAW264.7 cells by Galectin-9.
Lv R, Bao Q, Li Y. Lv R, et al. Mol Med Rep. 2017 Dec;16(6):9111-9119. doi: 10.3892/mmr.2017.7719. Epub 2017 Oct 4. Mol Med Rep. 2017. PMID: 28990062
Galectin-9 (Gal-9), a member of beta-galactoside lectin, is involved many processes of T cell-mediated diseases (such as autoimmune diseases and asthma) and immunomodulation of macrophages. ...Specific expression and secretion patterns of cytokines, transcription fa
Galectin-9 (Gal-9), a member of beta-galactoside lectin, is involved many processes of T cell-mediated diseases (such as autoi
The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis.
de Jong CGHM, Gabius HJ, Baron W. de Jong CGHM, et al. Cell Mol Life Sci. 2020 Apr;77(7):1289-1317. doi: 10.1007/s00018-019-03327-7. Epub 2019 Oct 18. Cell Mol Life Sci. 2020. PMID: 31628495 Free PMC article. Review.
Such a perspective is given by the emerging functional profile of galectins. They form a family of tissue lectins, which are potent effectors in processes as diverse as adhesion, apoptosis, immune mediator release or migration. ...Evidence is arising for a cooperati …
Such a perspective is given by the emerging functional profile of galectins. They form a family of tissue lectins, which are potent e …
Immunomodulatory Factors Galectin-9 and Interferon-Gamma Synergize to Induce Expression of Rate-Limiting Enzymes of the Kynurenine Pathway in the Mouse Hippocampus.
Brooks AK, Lawson MA, Rytych JL, Yu KC, Janda TM, Steelman AJ, McCusker RH. Brooks AK, et al. Front Immunol. 2016 Oct 17;7:422. doi: 10.3389/fimmu.2016.00422. eCollection 2016. Front Immunol. 2016. PMID: 27799931 Free PMC article.
Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenine Pathway. Galectins, like pro-inflammatory cytokines, play a role in neuroinflammation and the pathogenesis of several neurological disorders but without a clearly defi …
Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenine Pathway. Galectins, like pro-inflammat
Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy.
Souza BSF, da Silva KN, Silva DN, Rocha VPC, Paredes BD, Azevedo CM, Nonaka CK, Carvalho GB, Vasconcelos JF, Dos Santos RR, Soares MBP. Souza BSF, et al. Stem Cells Int. 2017;2017:3282656. doi: 10.1155/2017/3282656. Epub 2017 Jul 10. Stem Cells Int. 2017. PMID: 28769980 Free PMC article.
Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a crit …
Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In c …
The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist.
Forsman H, Salomonsson E, Onnheim K, Karlsson J, Björstad A, Leffler H, Bylund J, Karlsson A, Dahlgren C. Forsman H, et al. Glycobiology. 2008 Nov;18(11):905-12. doi: 10.1093/glycob/cwn081. Epub 2008 Aug 25. Glycobiology. 2008. PMID: 18725453
Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly regulated process that involves different mechanisms depending on which …
Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process k …
The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.
Corrêa MP, Areias LL, Correia-Silva RD, D'Ávila SCGP, Leopoldino AM, Greco KV, Gil CD. Corrêa MP, et al. Cells. 2021 Apr 20;10(4):947. doi: 10.3390/cells10040947. Cells. 2021. PMID: 33923930 Free PMC article.
Galectin-9 (Gal-9) is a beta-galactoside-binding protein with a variety of biological functions related to immune response. ...Overall, increased levels of Gal-9 in AD skin contribute to the control of inflammatory response and the proliferative process of ke
Galectin-9 (Gal-9) is a beta-galactoside-binding protein with a variety of biological functions related to immune response. ...Overal
Intraperitoneal administration of mesenchymal stem cells ameliorates acute dextran sulfate sodium-induced colitis by suppressing dendritic cells.
Nikolic A, Simovic Markovic B, Gazdic M, Randall Harrell C, Fellabaum C, Jovicic N, Djonov V, Arsenijevic N, L Lukic M, Stojkovic M, Volarevic V. Nikolic A, et al. Biomed Pharmacother. 2018 Apr;100:426-432. doi: 10.1016/j.biopha.2018.02.060. Epub 2018 Feb 22. Biomed Pharmacother. 2018. PMID: 29471245
Dendritic cells (DCs) have important pathogenic role in the induction and progression of ulcerative colitis (UC), but their role in mesenchymal stem cells (MSCs)-mediated suppression of colon injury and inflammation is not revealed. ...Through the secretion of im
Dendritic cells (DCs) have important pathogenic role in the induction and progression of ulcerative colitis (UC), but their role
Galectin-Levels Are Elevated in Infants Born Preterm Due to Amniotic Infection and Rapidly Decline in the Neonatal Period.
Faust K, Freitag N, Barrientos G, Hartel C, Blois SM. Faust K, et al. Front Immunol. 2021 Feb 25;11:599104. doi: 10.3389/fimmu.2020.599104. eCollection 2020. Front Immunol. 2021. PMID: 33717050 Free PMC article. Clinical Trial.
Galectin (gal)-1, -3, and -9 are members of a family of glycan binding proteins that mediate complex interactions between decidual, inflammatory and trophoblast cells modulating several processes during gestation, control of the maternal immune system, and pa
Galectin (gal)-1, -3, and -9 are members of a family of glycan binding proteins that mediate complex interactions between decidual,
Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Treatment of Viral Diseases.
Harrell CR, Popovska Jovicic B, Djonov V, Volarevic V. Harrell CR, et al. Pathogens. 2021 Apr 1;10(4):409. doi: 10.3390/pathogens10040409. Pathogens. 2021. PMID: 33915728 Free PMC article. Review.
Mesenchymal stem cells (MSCs) are adult, immunomodulatory stem cells which reside in almost all postnatal tissues. Viral antigens and damage-associated molecular patterns released from injured and infected cells activate MSCs, which elicit strong antiviral immune response. …
Mesenchymal stem cells (MSCs) are adult, immunomodulatory stem cells which reside in almost all postnatal tissues. Viral antigens and …
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