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Roles of the insular cortex in the modulation of pain: insights from brain lesions.
Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, Coghill RC. Starr CJ, et al. J Neurosci. 2009 Mar 4;29(9):2684-94. doi: 10.1523/JNEUROSCI.5173-08.2009. J Neurosci. 2009. PMID: 19261863 Free PMC article.
However, the role of the insular cortex in such modulatory processes remains poorly understood. Two individuals with extensive lesions to the insula were examined to better understand the contribution of this brain region to the generation of su …
However, the role of the insular cortex in such modulatory processes remains poorly understood. Two individuals with ex …
Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety.
Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP, Wang Y. Wang GQ, et al. Nat Commun. 2015 Jul 16;6:7660. doi: 10.1038/ncomms8660. Nat Commun. 2015. PMID: 26179626 Free PMC article.
Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of pain sensation and anxiety-like behaviours. ...Together, our findings provide novel insights into the role of PL excitator …
Here we demonstrate a role for excitatory neurons in the prelimbic cortex (PL), a sub-region of mPFC, in the regulation of …
Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats.
Cardoso-Cruz H, Dourado M, Monteiro C, Galhardo V. Cardoso-Cruz H, et al. Eur J Pain. 2018 May;22(5):1002-1015. doi: 10.1002/ejp.1186. Epub 2018 Jan 26. Eur J Pain. 2018. PMID: 29377353
RESULTS: Our results show that the peripheral nerve lesion caused a disruption in sWM and hippocampus spike activity and that disruption was maximized by the systemic administration of the D2r antagonist raclopride. ...SIGNIFICANCE: This study provides new insights
RESULTS: Our results show that the peripheral nerve lesion caused a disruption in sWM and hippocampus spike activity and that disrupt …
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