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Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion.
Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel JB, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. Franck G, et al. Circ Res. 2018 Jun 22;123(1):33-42. doi: 10.1161/CIRCRESAHA.117.312494. Epub 2018 Mar 23. Circ Res. 2018. PMID: 29572206 Free PMC article.
In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal injury and thrombosis. PAD4 (peptidyl arginine deiminase 4) participates in NET formation, but an understanding of this enzyme's …
In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal i …
Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity.
Molinaro R, Yu M, Sausen G, Bichsel CA, Corbo C, Folco EJ, Lee GY, Liu Y, Tesmenitsky Y, Shvartz E, Sukhova GK, Kloss F, Croce KJ, Farokhzad OC, Shi J, Libby P. Molinaro R, et al. Cardiovasc Res. 2021 Nov 22;117(13):2652-2663. doi: 10.1093/cvr/cvab074. Cardiovasc Res. 2021. PMID: 33751034 Free PMC article.
We recently reported that NETs amplify and propagate the endothelial damage at the site of arterial lesions that recapitulate superficial erosion in mice. We showed that genetic loss of protein arginine deiminase (PAD)-4 function inhibited NETosis and preserved endo …
We recently reported that NETs amplify and propagate the endothelial damage at the site of arterial lesions that recapitulate superfi …