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Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.
Rolink A, Kudo A, Karasuyama H, Kikuchi Y, Melchers F. Rolink A, et al. EMBO J. 1991 Feb;10(2):327-36. EMBO J. 1991. PMID: 1991449 Free PMC article.
Cell lines and clones were established from PB76-positive mouse fetal liver at day 13 and 14 of gestation, which proliferated with division times of a day in serum-substituted cultures under the stimulatory influence of adherent stromal cells and the cytokine IL-7 for peri …
Cell lines and clones were established from PB76-positive mouse fetal liver at day 13 and 14 of gestation, which proliferated with division …
Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation.
Santiago-Raber ML, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A, Izui S. Santiago-Raber ML, et al. Among authors: rolink a. J Autoimmun. 2010 Jun;34(4):349-55. doi: 10.1016/j.jaut.2010.01.001. Epub 2010 Feb 10. J Autoimmun. 2010. PMID: 20149596
The development of systemic lupus is accelerated by the Yaa (Y-linked autoimmune acceleration) mutation, which is the consequence of a translocation of the telomeric end containing the Tlr7 gene from the X chromosome onto the Y chromosome. ...These results contrasted with …
The development of systemic lupus is accelerated by the Yaa (Y-linked autoimmune acceleration) mutation, which is the consequence of a
B cell tolerance--how to make it and how to break it.
Melchers F, Rolink AR. Melchers F, et al. Among authors: rolink ar. Curr Top Microbiol Immunol. 2006;305:1-23. doi: 10.1007/3-540-29714-6_1. Curr Top Microbiol Immunol. 2006. PMID: 16724798 Review.
A series of checkpoints for antigen receptor fitness and specificity during B cell development ensures the elimination or anergy of primary, high-avidity-autoantigen-reactive B cells. ...Furthermore, whenever tolerance of helper T cells to a part of an autoantigen i
A series of checkpoints for antigen receptor fitness and specificity during B cell development ensures the elimination or anergy of p
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.
Yu W, Nagaoka H, Jankovic M, Misulovin Z, Suh H, Rolink A, Melchers F, Meffre E, Nussenzweig MC. Yu W, et al. Among authors: rolink a. Nature. 1999 Aug 12;400(6745):682-7. doi: 10.1038/23287. Nature. 1999. PMID: 10458165
Here we investigate the regulation of RAG expression in transgenic mice carrying a bacterial artificial chromosome that encodes a green fluorescent protein reporter instead of RAG2. ...Our findings may help to reconcile a series of apparently contradictory ob …
Here we investigate the regulation of RAG expression in transgenic mice carrying a bacterial artificial chromosome that encodes a
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments.
Nutt SL, Morrison AM, Dörfler P, Rolink A, Busslinger M. Nutt SL, et al. Among authors: rolink a. EMBO J. 1998 Apr 15;17(8):2319-33. doi: 10.1093/emboj/17.8.2319. EMBO J. 1998. PMID: 9545244 Free PMC article.
We have now taken advantage of cultured pre-BI cells of wild-type and Pax-5 mutant bone marrow to screen a large panel of B lymphoid genes for additional BSAP target genes. ...Distinct regulatory mechanisms of BSAP were revealed by reconstituting Pax-5-deficient pre-BI cel …
We have now taken advantage of cultured pre-BI cells of wild-type and Pax-5 mutant bone marrow to screen a large panel of B lymphoid …
Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors.
Ceredig R, Andersson J, Melchers F, Rolink A. Ceredig R, et al. Among authors: rolink a. Eur J Immunol. 1999 Sep;29(9):2797-807. doi: 10.1002/(SICI)1521-4141(199909)29:09<2797::AID-IMMU2797>3.0.CO;2-8. Eur J Immunol. 1999. PMID: 10508254
While the introduction of deregulated IL-7 production does not change the size of the pro-B and pre-B I compartments in the bone marrow of wild-type and lambda5-/- mice, it increases these compartments 2.5- to fivefold in mice which cannot make immature and mature B cells, i. e. …
While the introduction of deregulated IL-7 production does not change the size of the pro-B and pre-B I compartments in the bone marrow of w …
B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages.
Engel H, Rolink A, Weiss S. Engel H, et al. Among authors: rolink a. Eur J Immunol. 1999 Jul;29(7):2167-76. doi: 10.1002/(SICI)1521-4141(199907)29:07<2167::AID-IMMU2167>3.0.CO;2-H. Eur J Immunol. 1999. PMID: 10427979
Activation--a prerequisite of rearrangement--was monitored by analyzing transcription of unrearranged J-C clusters. Upon in vitro differentiation of a rearrangement-deficient pro/pre-B line, germ-line transcripts of the lambda J-C clusters, that are newly described …
Activation--a prerequisite of rearrangement--was monitored by analyzing transcription of unrearranged J-C clusters. Upon in vitro dif …
Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A. Colonna M, et al. Among authors: rolink a. J Immunol. 1998 Apr 1;160(7):3096-100. J Immunol. 1998. PMID: 9531263
While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. ...
While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors disp …
The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4.
D'Apuzzo M, Rolink A, Loetscher M, Hoxie JA, Clark-Lewis I, Melchers F, Baggiolini M, Moser B. D'Apuzzo M, et al. Among authors: rolink a. Eur J Immunol. 1997 Jul;27(7):1788-93. doi: 10.1002/eji.1830270729. Eur J Immunol. 1997. PMID: 9247593
SDF-1 was recently shown to be a chemokine which is chemotactic for different types of leukocytes and acts via the chemokine receptor CXCR4. ...In early B cell precursors, SDF-1 induced intracellular Ca2+ mobilization and in vitro migration with a potency and effica …
SDF-1 was recently shown to be a chemokine which is chemotactic for different types of leukocytes and acts via the chemokine receptor …
Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro.
Ceredig R, ten Boekel E, Rolink A, Melchers F, Andersson J. Ceredig R, et al. Among authors: rolink a. Int Immunol. 1998 Jan;10(1):49-59. doi: 10.1093/intimm/10.1.49. Int Immunol. 1998. PMID: 9488155
FLOC B cell development proceeds to mature IgM+, IgD+ and CD23+ lipopolysaccharide-reactive B cells within a culture period of 5-6 days. ...FLOC from embryos of mice with targeted mutations in the RAG-2 and lambda5 genes, which cannot expand by proliferative expansion of t …
FLOC B cell development proceeds to mature IgM+, IgD+ and CD23+ lipopolysaccharide-reactive B cells within a culture period of 5-6 da …
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