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Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial.
Harrison SA, Frias JP, Neff G, Abrams GA, Lucas KJ, Sanchez W, Gogia S, Sheikh MY, Behling C, Bedossa P, Shao L, Chan D, Fong E, de Temple B, Shringarpure R, Tillman EJ, Rolph T, Cheng A, Yale K; HARMONY Study Group. Harrison SA, et al. Among authors: rolph t. Lancet Gastroenterol Hepatol. 2023 Dec;8(12):1080-1093. doi: 10.1016/S2468-1253(23)00272-8. Epub 2023 Oct 3. Lancet Gastroenterol Hepatol. 2023. PMID: 37802088 Clinical Trial.
Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.
Harrison SA, Frias JP, Lucas KJ, Reiss G, Neff G, Bollepalli S, Su Y, Chan D, Tillman EJ, Moulton A, de Temple B, Zari A, Shringarpure R, Rolph T, Cheng A, Yale K. Harrison SA, et al. Among authors: rolph t. Clin Gastroenterol Hepatol. 2024 Mar 4:S1542-3565(24)00226-X. doi: 10.1016/j.cgh.2024.02.022. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 38447814 Free article.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, Stevens RD, Koves TR, Muoio DM, Brozinick JT, Gimeno RE, Brosnan MJ, Rolph TP, Kraus WE, Shah SH, Newgard CB. White PJ, et al. Among authors: rolph tp. Cell Rep. 2020 Nov 10;33(6):108375. doi: 10.1016/j.celrep.2020.108375. Cell Rep. 2020. PMID: 33176135 Free PMC article.
51 results