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Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.
Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA. Winkler ML, et al. Among authors: romagnoli c. J Med Chem. 2013 Feb 14;56(3):1084-97. doi: 10.1021/jm301490d. Epub 2013 Feb 4. J Med Chem. 2013. PMID: 23252553 Free PMC article.
Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design.
Rojas LJ, Taracila MA, Papp-Wallace KM, Bethel CR, Caselli E, Romagnoli C, Winkler ML, Spellberg B, Prati F, Bonomo RA. Rojas LJ, et al. Among authors: romagnoli c. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1751-9. doi: 10.1128/AAC.02641-15. Antimicrob Agents Chemother. 2016. PMID: 26729496 Free PMC article.
503 results