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Inflammasome is a central player in the induction of obesity and insulin resistance.
Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD. Stienstra R, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9. doi: 10.1073/pnas.1100255108. Epub 2011 Aug 29. Proc Natl Acad Sci U S A. 2011. PMID: 21876127 Free PMC article.
Methods for quantifying adipose tissue insulin resistance in overweight/obese humans.
Ter Horst KW, van Galen KA, Gilijamse PW, Hartstra AV, de Groot PF, van der Valk FM, Ackermans MT, Nieuwdorp M, Romijn JA, Serlie MJ. Ter Horst KW, et al. Int J Obes (Lond). 2017 Aug;41(8):1288-1294. doi: 10.1038/ijo.2017.110. Epub 2017 May 3. Int J Obes (Lond). 2017. PMID: 28465607
Insulin resistance in obesity can be reliably identified from fasting plasma insulin.
ter Horst KW, Gilijamse PW, Koopman KE, de Weijer BA, Brands M, Kootte RS, Romijn JA, Ackermans MT, Nieuwdorp M, Soeters MR, Serlie MJ. ter Horst KW, et al. Int J Obes (Lond). 2015 Dec;39(12):1703-9. doi: 10.1038/ijo.2015.125. Epub 2015 Jul 9. Int J Obes (Lond). 2015. PMID: 26155920
The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system.
Coomans CP, Geerling JJ, van den Berg SA, van Diepen HC, Garcia-Tardón N, Thomas A, Schröder-van der Elst JP, Ouwens DM, Pijl H, Rensen PC, Havekes LM, Guigas B, Romijn JA. Coomans CP, et al. Br J Pharmacol. 2013 Oct;170(4):908-18. doi: 10.1111/bph.12338. Br J Pharmacol. 2013. PMID: 23957854 Free PMC article.
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.
de Leeuw van Weenen JE, Parlevliet ET, Maechler P, Havekes LM, Romijn JA, Ouwens DM, Pijl H, Guigas B. de Leeuw van Weenen JE, et al. Biochem Pharmacol. 2010 Jun 15;79(12):1827-36. doi: 10.1016/j.bcp.2010.01.029. Epub 2010 Feb 4. Biochem Pharmacol. 2010. PMID: 20138024
Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation.
Finken MJ, Keijzer-Veen MG, Dekker FW, Frölich M, Walther FJ, Romijn JA, van der Heijden BJ, Wit JM; Dutch POPS-19 Collaborative Study Group. Finken MJ, et al. Arch Dis Child Fetal Neonatal Ed. 2008 Nov;93(6):F442-7. doi: 10.1136/adc.2007.128470. Epub 2008 May 1. Arch Dis Child Fetal Neonatal Ed. 2008. PMID: 18450806 Clinical Trial.
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