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The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. Hsieh AC, et al. Among authors: rommel c. Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912. Nature. 2012. PMID: 22367541 Free PMC article.
Ras--a versatile cellular switch.
Rommel C, Hafen E. Rommel C, et al. Curr Opin Genet Dev. 1998 Aug;8(4):412-8. doi: 10.1016/s0959-437x(98)80111-1. Curr Opin Genet Dev. 1998. PMID: 9729716 Review.
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, Crabbe T, Finan P, Jones G, Jackson S, Camps M, Rommel C, Wymann M, Hirsch E, Hawkins P, Stephens L. Ferguson GJ, et al. Among authors: rommel c. Nat Cell Biol. 2007 Jan;9(1):86-91. doi: 10.1038/ncb1517. Epub 2006 Dec 17. Nat Cell Biol. 2007. PMID: 17173040
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL. Winkler DG, et al. Among authors: rommel c. Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7. Chem Biol. 2013. PMID: 24211136
PI3K and cancer: lessons, challenges and opportunities.
Fruman DA, Rommel C. Fruman DA, et al. Among authors: rommel c. Nat Rev Drug Discov. 2014 Feb;13(2):140-56. doi: 10.1038/nrd4204. Nat Rev Drug Discov. 2014. PMID: 24481312 Free PMC article. Review.
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL. Berndt A, et al. Among authors: rommel c. Nat Chem Biol. 2010 Feb;6(2):117-24. doi: 10.1038/nchembio.293. Nat Chem Biol. 2010. PMID: 20081827 Free PMC article.
106 results