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Fructose, but not dextrose, accelerates the progression of chronic kidney disease.
Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T. Gersch MS, et al. Among authors: Roncal C. Am J Physiol Renal Physiol. 2007 Oct;293(4):F1256-61. doi: 10.1152/ajprenal.00181.2007. Epub 2007 Aug 1. Am J Physiol Renal Physiol. 2007. PMID: 17670904
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver.
Sánchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, Le M, Nakagawa T, Lan HY, Yu X, Johnson RJ. Sánchez-Lozada LG, et al. Among authors: Roncal C. Eur J Nutr. 2010 Feb;49(1):1-9. doi: 10.1007/s00394-009-0042-x. Epub 2009 Jul 22. Eur J Nutr. 2010. PMID: 19626358 Free PMC article.
Control rats were fed normal rat chow (C). All rats were pair fed and were followed for 4 months. After killing, blood chemistries and liver tissue were examined. RESULTS: Both FG-fed- and S-fed rats developed early features of metabolic syndrome when compared with C. In addition, both diets induced hepatic alterations, including variable increases in hepatic TG accumulation and fatty liver, an increase in uric acid content in the liver, as well as an increase in hepatic levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) measured in liver homogenates. ...
Control rats were fed normal rat chow (C). All rats were pair fed and were followed for 4 months. After killing, blood chemistries an …
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T. Johnson RJ, et al. Among authors: Roncal C. Endocr Rev. 2009 Feb;30(1):96-116. doi: 10.1210/er.2008-0033. Epub 2009 Jan 16. Endocr Rev. 2009. PMID: 19151107 Free PMC article. Review.
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
Johnson RJ, Sautin YY, Oliver WJ, Roncal C, Mu W, Gabriela Sanchez-Lozada L, Rodriguez-Iturbe B, Nakagawa T, Benner SA. Johnson RJ, et al. Among authors: Roncal C. J Comp Physiol B. 2009 Jan;179(1):67-76. doi: 10.1007/s00360-008-0291-7. Epub 2008 Jul 23. J Comp Physiol B. 2009. PMID: 18649082 Free PMC article. Review.
We further suggest that there is a complex interplay between fructose, uric acid and vitamin C, with fructose and uric acid stimulating the foraging response and vitamin C countering this response. ...
We further suggest that there is a complex interplay between fructose, uric acid and vitamin C, with fructose and uric acid stimulati …
Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice.
Ouyang X, Le TH, Roncal C, Gersch C, Herrera-Acosta J, Rodriguez-Iturbe B, Coffman TM, Johnson RJ, Mu W. Ouyang X, et al. Among authors: Roncal C. Am J Physiol Renal Physiol. 2005 Oct;289(4):F902-10. doi: 10.1152/ajprenal.00141.2005. Epub 2005 May 31. Am J Physiol Renal Physiol. 2005. PMID: 15928210
Dietary fructose causes tubulointerstitial injury in the normal rat kidney.
Nakayama T, Kosugi T, Gersch M, Connor T, Sanchez-Lozada LG, Lanaspa MA, Roncal C, Perez-Pozo SE, Johnson RJ, Nakagawa T. Nakayama T, et al. Among authors: Roncal C. Am J Physiol Renal Physiol. 2010 Mar;298(3):F712-20. doi: 10.1152/ajprenal.00433.2009. Epub 2010 Jan 13. Am J Physiol Renal Physiol. 2010. PMID: 20071464 Free PMC article.
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice.
Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T. Kosugi T, et al. Among authors: Roncal C. Am J Physiol Renal Physiol. 2009 Aug;297(2):F481-8. doi: 10.1152/ajprenal.00092.2009. Epub 2009 May 20. Am J Physiol Renal Physiol. 2009. PMID: 19458127 Free PMC article.
Fructose induces the inflammatory molecule ICAM-1 in endothelial cells.
Glushakova O, Kosugi T, Roncal C, Mu W, Heinig M, Cirillo P, Sánchez-Lozada LG, Johnson RJ, Nakagawa T. Glushakova O, et al. Among authors: Roncal C. J Am Soc Nephrol. 2008 Sep;19(9):1712-20. doi: 10.1681/ASN.2007121304. Epub 2008 May 28. J Am Soc Nephrol. 2008. PMID: 18508964 Free PMC article.
The conundrum of hyperuricemia, metabolic syndrome, and renal disease.
Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, Mu W, Sánchez-Lozada LG, Johnson RJ. Nakagawa T, et al. Among authors: Roncal C. Intern Emerg Med. 2008 Dec;3(4):313-8. doi: 10.1007/s11739-008-0141-3. Epub 2008 Mar 5. Intern Emerg Med. 2008. PMID: 18320146 Free PMC article. Review.
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