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Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
Kleiman RJ, Chapin DS, Christoffersen C, Freeman J, Fonseca KR, Geoghegan KF, Grimwood S, Guanowsky V, Hajós M, Harms JF, Helal CJ, Hoffmann WE, Kocan GP, Majchrzak MJ, McGinnis D, McLean S, Menniti FS, Nelson F, Roof R, Schmidt AW, Seymour PA, Stephenson DT, Tingley FD, Vanase-Frawley M, Verhoest PR, Schmidt CJ. Kleiman RJ, et al. Among authors: roof r. J Pharmacol Exp Ther. 2012 May;341(2):396-409. doi: 10.1124/jpet.111.191353. Epub 2012 Feb 10. J Pharmacol Exp Ther. 2012. PMID: 22328573
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.
Banala AK, Levy BA, Khatri SS, Furman CA, Roof RA, Mishra Y, Griffin SA, Sibley DR, Luedtke RR, Newman AH. Banala AK, et al. Among authors: roof ra. J Med Chem. 2011 May 26;54(10):3581-94. doi: 10.1021/jm200288r. Epub 2011 May 2. J Med Chem. 2011. PMID: 21495689 Free PMC article.
Synthesis and SAR of tolylamine 5-HT6 antagonists.
Singer JM, Wilson MW, Johnson PD, Graham SR, Cooke LW, Roof RL, Boxer PA, Gold LH, Meltzer LT, Janssen A, Roush N, Campbell JE, Su TZ, Hurst SI, Stoner CL, Schwarz JB. Singer JM, et al. Among authors: roof rl. Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. doi: 10.1016/j.bmcl.2009.03.077. Epub 2009 Mar 25. Bioorg Med Chem Lett. 2009. PMID: 19346128
Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist.
Patel SD, Habeski WM, Min H, Zhang J, Roof R, Snyder B, Bora G, Campbell B, Li C, Hidayetoglu D, Johnson DS, Chaudhry A, Charlton ME, Kablaoui NM. Patel SD, et al. Among authors: roof r. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5689-93. doi: 10.1016/j.bmcl.2008.08.055. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2008. PMID: 18799310
Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.
Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Roof RA, et al. Chem Biol Drug Des. 2008 Aug;72(2):111-9. doi: 10.1111/j.1747-0285.2008.00687.x. Epub 2008 Jul 15. Chem Biol Drug Des. 2008. PMID: 18637987 Free PMC article.
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