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Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.
Baars MJD, Douma T, Simeonov DR, Myers DR, Kulhanek K, Banerjee S, Zwakenberg S, Baltissen MP, Amini M, de Roock S, van Wijk F, Vermeulen M, Marson A, Roose JP, Vercoulen Y. Baars MJD, et al. Among authors: roose jp. Eur J Immunol. 2021 Feb;51(2):471-482. doi: 10.1002/eji.201948451. Epub 2020 Nov 16. Eur J Immunol. 2021. PMID: 33065764 Free PMC article.
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. Kortum RL, et al. Among authors: roose jp. J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3. J Immunol. 2013. PMID: 23209318 Free PMC article.
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. Hartzell C, et al. Among authors: roose jp. Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848. Sci Signal. 2013. PMID: 23532335 Free PMC article.
Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.
Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. Daley SR, et al. Among authors: roose jp. Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020. Elife. 2013. PMID: 24336796 Free PMC article.
Lost GRP on cytotoxicity?
Roose JP. Roose JP. Nat Immunol. 2016 Nov 16;17(12):1339-1340. doi: 10.1038/ni.3620. Nat Immunol. 2016. PMID: 27849207 No abstract available.
Tonic Signals: Why Do Lymphocytes Bother?
Myers DR, Zikherman J, Roose JP. Myers DR, et al. Among authors: roose jp. Trends Immunol. 2017 Nov;38(11):844-857. doi: 10.1016/j.it.2017.06.010. Epub 2017 Jul 25. Trends Immunol. 2017. PMID: 28754596 Free PMC article. Review.
84 results