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Page 1
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Parmentier-Batteur S, Hutson PH, Menzel K, Uslaner JM, Mattson BA, O'Brien JA, Magliaro BC, Forest T, Stump CA, Tynebor RM, Anthony NJ, Tucker TJ, Zhang XF, Gomez R, Huszar SL, Lambeng N, Fauré H, Le Poul E, Poli S, Rosahl TW, Rocher JP, Hargreaves R, Williams TM. Parmentier-Batteur S, et al. Among authors: rosahl tw. Neuropharmacology. 2014 Jul;82:161-73. doi: 10.1016/j.neuropharm.2012.12.003. Epub 2013 Jan 2. Neuropharmacology. 2014. PMID: 23291536
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, Bromidge F, Owens AP, Huscroft I, Myers J, Rupniak NM, Patel S, Whiting PJ, Hutson PH, Fone KC, Biello SM, Kulagowski JJ, McAllister G. Guscott M, et al. Among authors: rosahl tw. Neuropharmacology. 2005 Mar;48(4):492-502. doi: 10.1016/j.neuropharm.2004.11.015. Neuropharmacology. 2005. PMID: 15755477
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor.
Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH. Guscott MR, et al. Among authors: rosahl tw. Neuropharmacology. 2003 Jun;44(8):1031-7. doi: 10.1016/s0028-3908(03)00117-5. Neuropharmacology. 2003. PMID: 12763096
Antinociceptive effects of potent, selective and brain penetrant muscarinic M4 positive allosteric modulators in rodent pain models.
Grauer SM, Sanoja R, Poulin D, Rashid H, Jochnowitz N, Calhoun M, Zwilling D, Varty GB, Rosahl TW, Meziane H, Mittlelhaeuser C, Mazzola R, Morrow J, Smith SM, Henze D, Marcus J. Grauer SM, et al. Among authors: rosahl tw. Brain Res. 2020 Jun 15;1737:146814. doi: 10.1016/j.brainres.2020.146814. Epub 2020 Mar 29. Brain Res. 2020. PMID: 32234514
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.
Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, Lambert JJ, Dawson GR, McKernan R, Whiting PJ, Wafford KA. Reynolds DS, et al. Among authors: rosahl tw. J Neurosci. 2003 Sep 17;23(24):8608-17. doi: 10.1523/JNEUROSCI.23-24-08608.2003. J Neurosci. 2003. PMID: 13679430 Free PMC article.
Transgenic animals relevant to Alzheimer's disease.
Seabrook GR, Rosahl TW. Seabrook GR, et al. Among authors: rosahl tw. Neuropharmacology. 1999 Jan;38(1):1-17. doi: 10.1016/s0028-3908(98)00170-1. Neuropharmacology. 1999. PMID: 10193895 Review.
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.
Hastings NB, Wang X, Song L, Butts BD, Grotz D, Hargreaves R, Fred Hess J, Hong KK, Huang CR, Hyde L, Laverty M, Lee J, Levitan D, Lu SX, Maguire M, Mahadomrongkul V, McEachern EJ, Ouyang X, Rosahl TW, Selnick H, Stanton M, Terracina G, Vocadlo DJ, Wang G, Duffy JL, Parker EM, Zhang L. Hastings NB, et al. Among authors: rosahl tw. Mol Neurodegener. 2017 May 18;12(1):39. doi: 10.1186/s13024-017-0181-0. Mol Neurodegener. 2017. PMID: 28521765 Free PMC article.
68 results