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229 results

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NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. Samokhin AO, et al. Among authors: rosas io. Sci Transl Med. 2018 Jun 13;10(445):eaap7294. doi: 10.1126/scitranslmed.aap7294. Sci Transl Med. 2018. PMID: 29899023 Free PMC article.
Autophagy in idiopathic pulmonary fibrosis.
Patel AS, Lin L, Geyer A, Haspel JA, An CH, Cao J, Rosas IO, Morse D. Patel AS, et al. Among authors: rosas io. PLoS One. 2012;7(7):e41394. doi: 10.1371/journal.pone.0041394. Epub 2012 Jul 18. PLoS One. 2012. PMID: 22815997 Free PMC article.
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.
Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Nakahira K, et al. Among authors: rosas io. PLoS Med. 2013 Dec;10(12):e1001577; discussion e1001577. doi: 10.1371/journal.pmed.1001577. Epub 2013 Dec 31. PLoS Med. 2013. PMID: 24391478 Free PMC article.
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: rosas io. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. White K, et al. EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511. EMBO Mol Med. 2015. PMID: 25825391 Free PMC article.
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.
Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. Yung LM, et al. Among authors: rosas io. Sci Transl Med. 2020 May 13;12(543):eaaz5660. doi: 10.1126/scitranslmed.aaz5660. Sci Transl Med. 2020. PMID: 32404506 Free PMC article.
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models.
Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS. Hettiarachchi SU, et al. Among authors: rosas io. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. doi: 10.1126/scitranslmed.aay3724. Sci Transl Med. 2020. PMID: 33115948
229 results