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Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scheller J, Ohnesorge N, Rose-John S. Scheller J, et al. Scand J Immunol. 2006 May;63(5):321-9. doi: 10.1111/j.1365-3083.2006.01750.x. Scand J Immunol. 2006. PMID: 16640655 Review.
The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand.
Zohlnhöfer D, Graeve L, Rose-John S, Schooltink H, Dittrich E, Heinrich PC. Zohlnhöfer D, et al. FEBS Lett. 1992 Jul 20;306(2-3):219-22. doi: 10.1016/0014-5793(92)81004-6. FEBS Lett. 1992. PMID: 1321736
Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells.
Mackiewicz A, Rose-John S, Schooltink H, Laciak M, Górny A, Heinrich PC. Mackiewicz A, et al. FEBS Lett. 1992 Jul 20;306(2-3):257-61. doi: 10.1016/0014-5793(92)81012-b. FEBS Lett. 1992. PMID: 1321738
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1.
Kordula T, Güttgemann I, Rose-John S, Roeb E, Osthues A, Tschesche H, Koj A, Heinrich PC, Graeve L. Kordula T, et al. FEBS Lett. 1992 Nov 23;313(2):143-7. doi: 10.1016/0014-5793(92)81431-k. FEBS Lett. 1992. PMID: 1330702
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Müllberg J, Schooltink H, Stoyan T, Heinrich PC, Rose-John S. Müllberg J, et al. Biochem Biophys Res Commun. 1992 Dec 15;189(2):794-800. doi: 10.1016/0006-291x(92)92272-y. Biochem Biophys Res Commun. 1992. PMID: 1335247
Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells.
Schooltink H, Schmitz-Van de Leur H, Heinrich PC, Rose-John S. Schooltink H, et al. FEBS Lett. 1992 Feb 10;297(3):263-5. doi: 10.1016/0014-5793(92)80552-r. FEBS Lett. 1992. PMID: 1544406
Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.
Schooltink H, Stoyan T, Lenz D, Schmitz H, Hirano T, Kishimoto T, Heinrich PC, Rose-John S. Schooltink H, et al. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659. Biochem J. 1991. PMID: 1872801 Free PMC article.
Studies on the structure and regulation of the human hepatic interleukin-6 receptor.
Rose-John S, Schooltink H, Lenz D, Hipp E, Dufhues G, Schmitz H, Schiel X, Hirano T, Kishimoto T, Heinrich PC. Rose-John S, et al. Eur J Biochem. 1990 May 31;190(1):79-83. doi: 10.1111/j.1432-1033.1990.tb15548.x. Eur J Biochem. 1990. PMID: 2163835
Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes, fibroblasts and endothelial cells.
Schiel X, Rose-John S, Dufhues G, Schooltink H, Gross V, Heinrich PC. Schiel X, et al. Eur J Immunol. 1990 Apr;20(4):883-7. doi: 10.1002/eji.1830200425. Eur J Immunol. 1990. PMID: 2347366
Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.
Ehlers M, Grötzinger J, deHon FD, Müllberg J, Brakenhoff JP, Liu J, Wollmer A, Rose-John S. Ehlers M, et al. J Immunol. 1994 Aug 15;153(4):1744-53. J Immunol. 1994. PMID: 7519211
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