Rose-John S - Search Results

1

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.

Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J. Sommer J, et al. J Biol Chem. 2012 Apr 20;287(17):13743-51. doi: 10.1074/jbc.M111.349167. J Biol Chem. 2012. PMID: 22523320 Free PMC article.

2

Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.

Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920 Free article.

3

Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.

Dittrich E, Rose-John S, Gerhartz C, Müllberg J, Stoyan T, Yasukawa K, Heinrich PC, Graeve L. Dittrich E, et al. J Biol Chem. 1994 Jul 22;269(29):19014-20. J Biol Chem. 1994. PMID: 8034658 Free article.

4

Development of a human interleukin-6 receptor antagonist.

Brakenhoff JP, de Hon FD, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich PC, Content J, Aarden LA. Brakenhoff JP, et al. J Biol Chem. 1994 Jan 7;269(1):86-93. J Biol Chem. 1994. PMID: 8276883 Free article.

5

Intracellular retention of interleukin-6 abrogates signaling.

Rose-John S, Schooltink H, Schmitz-Van de Leur H, Müllberg J, Heinrich PC, Graeve L. Rose-John S, et al. J Biol Chem. 1993 Oct 15;268(29):22084-91. J Biol Chem. 1993. PMID: 8408066 Free article.

6

The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.

Ozbek S, Grötzinger J, Krebs B, Fischer M, Wollmer A, Jostock T, Müllberg J, Rose-John S. Ozbek S, et al. J Biol Chem. 1998 Aug 14;273(33):21374-9. doi: 10.1074/jbc.273.33.21374. J Biol Chem. 1998. PMID: 9694899 Free article.

7

A new type of cytokine receptor antagonist directly targeting gp130.

Renné C, Kallen KJ, Müllberg J, Jostock T, Grötzinger J, Rose-John S. Renné C, et al. J Biol Chem. 1998 Oct 16;273(42):27213-9. doi: 10.1074/jbc.273.42.27213. J Biol Chem. 1998. PMID: 9765242 Free article.

8

The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

Rakemann T, Niehof M, Kubicka S, Fischer M, Manns MP, Rose-John S, Trautwein C. Rakemann T, et al. J Biol Chem. 1999 Jan 15;274(3):1257-66. doi: 10.1074/jbc.274.3.1257. J Biol Chem. 1999. PMID: 9880494 Free article.

9

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

Kallen KJ, Grötzinger J, Lelièvre E, Vollmer P, Aasland D, Renné C, Müllberg J, Myer zum Büschenfelde KH, Gascan H, Rose-John S. Kallen KJ, et al. J Biol Chem. 1999 Apr 23;274(17):11859-67. doi: 10.1074/jbc.274.17.11859. J Biol Chem. 1999. PMID: 10207005 Free article.

10

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.

Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ. Schuster B, et al. J Biol Chem. 2003 Mar 14;278(11):9528-35. doi: 10.1074/jbc.m210044200. J Biol Chem. 2003. PMID: 12643274 Free article.

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