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Interleukin-6 and its receptors: a highly regulated and dynamic system.
Wolf J, Rose-John S, Garbers C. Wolf J, et al. Cytokine. 2014 Nov;70(1):11-20. doi: 10.1016/j.cyto.2014.05.024. Epub 2014 Jun 28. Cytokine. 2014. PMID: 24986424 Review.
Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells.
Schooltink H, Schmitz-Van de Leur H, Heinrich PC, Rose-John S. Schooltink H, et al. FEBS Lett. 1992 Feb 10;297(3):263-5. doi: 10.1016/0014-5793(92)80552-r. FEBS Lett. 1992. PMID: 1544406
Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130.
de Hon FD, ten Boekel E, Herrman J, Clement C, Ehlers M, Taga T, Yasukawa K, Ohsugi Y, Kishimoto T, Rose-John S, et al. de Hon FD, et al. Cytokine. 1995 Jul;7(5):398-407. doi: 10.1006/cyto.1995.0055. Cytokine. 1995. PMID: 7578977
The soluble interleukin-6 receptor.
Rose-John S, Ehlers M, Grötzinger J, Müllberg J. Rose-John S, et al. Ann N Y Acad Sci. 1995 Jul 21;762:207-20; discussion 220-1. Ann N Y Acad Sci. 1995. PMID: 7668529 No abstract available.
Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.
Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920
Soluble interleukin 6 receptor is biologically active in vivo.
Mackiewicz A, Wiznerowicz M, Roeb E, Karczewska A, Nowak J, Heinrich PC, Rose-John S. Mackiewicz A, et al. Cytokine. 1995 Feb;7(2):142-9. doi: 10.1006/cyto.1995.1019. Cytokine. 1995. PMID: 7780033
The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor.
Horsten U, Schmitz-Van de Leur H, Müllberg J, Heinrich PC, Rose-John S. Horsten U, et al. FEBS Lett. 1995 Feb 20;360(1):43-6. doi: 10.1016/0014-5793(95)00053-c. FEBS Lett. 1995. PMID: 7875298
Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.
Gerhartz C, Dittrich E, Stoyan T, Rose-John S, Yasukawa K, Heinrich PC, Graeve L. Gerhartz C, et al. Eur J Biochem. 1994 Jul 1;223(1):265-74. doi: 10.1111/j.1432-1033.1994.tb18991.x. Eur J Biochem. 1994. PMID: 8033901
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Dittrich E, Rose-John S, Gerhartz C, Müllberg J, Stoyan T, Yasukawa K, Heinrich PC, Graeve L. Dittrich E, et al. J Biol Chem. 1994 Jul 22;269(29):19014-20. J Biol Chem. 1994. PMID: 8034658
Development of a human interleukin-6 receptor antagonist.
Brakenhoff JP, de Hon FD, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich PC, Content J, Aarden LA. Brakenhoff JP, et al. J Biol Chem. 1994 Jan 7;269(1):86-93. J Biol Chem. 1994. PMID: 8276883
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