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Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.
PLoS One. 2010 Sep 21;5(9):e12788. doi: 10.1371/journal.pone.0012788.
PLoS One. 2010.
PMID: 20877719
Free PMC article.
This approach proved successful in the identification of seven chemicals as novel inhibitors of lysosomal acid lipase (Rosenbaum et al, Biochim. Biophys. Acta. 2009, 1791:1155-1165)....
This approach proved successful in the identification of seven chemicals as novel inhibitors of lysosomal acid lipase (Rosenbaum et a …
Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
Rosenbaum AI, Rujoi M, Huang AY, Du H, Grabowski GA, Maxfield FR.
Rosenbaum AI, et al.
Biochim Biophys Acta. 2009 Dec;1791(12):1155-65. doi: 10.1016/j.bbalip.2009.08.005. Epub 2009 Aug 20.
Biochim Biophys Acta. 2009.
PMID: 19699313
Free PMC article.
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