Rosenberg SH - Search Results

1

1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors.

Martin SF, Austin RE, Oalmann CJ, Baker WR, Condon SL, deLara E, Rosenberg SH, Spina KP, Stein HH, Cohen J, et al. Martin SF, et al. Among authors: rosenberg sh. J Med Chem. 1992 May 15;35(10):1710-21. doi: 10.1021/jm00088a005. J Med Chem. 1992. PMID: 1588553

2

Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.

Rosenberg SH, Dellaria JF, Kempf DJ, Hutchins CW, Woods KW, Maki RG, de Lara E, Spina KP, Stein HH, Cohen J, et al. Rosenberg SH, et al. J Med Chem. 1990 Jun;33(6):1582-90. doi: 10.1021/jm00168a009. J Med Chem. 1990. PMID: 2187994

3

Renin inhibitors: C-terminal oxetanes as potent transition-state mimics.

Rosenberg SH, Spina KP, Stein H, Cohen J, Baker WR, Kleinert HD. Rosenberg SH, et al. Bioorg Med Chem. 1994 Sep;2(9):927-37. doi: 10.1016/s0968-0896(00)82042-8. Bioorg Med Chem. 1994. PMID: 7712128

4

Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors.

Dayton BD, Stein HH, Cohen J, Baker WR, Boyd SA, Condon SL, Donner BG, Fung AK, Luly JR, Rosenberg SH, et al. Dayton BD, et al. Among authors: rosenberg sh. Clin Chem. 1992 Nov;38(11):2239-43. Clin Chem. 1992. PMID: 1330373

5

Design of a well-absorbed renin inhibitor.

Rosenberg SH, Kleinert HD, Stein HH, Martin DL, Chekal MA, Cohen J, Egan DA, Tricarico KA, Baker WR. Rosenberg SH, et al. J Med Chem. 1991 Jan;34(1):469-71. doi: 10.1021/jm00105a073. J Med Chem. 1991. PMID: 1992151 No abstract available.

6

Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.

Rosenberg SH, Woods KW, Sham HL, Kleinert HD, Martin DL, Stein H, Cohen J, Egan DA, Bopp B, Merits I, et al. Rosenberg SH, et al. J Med Chem. 1990 Jul;33(7):1962-9. doi: 10.1021/jm00169a024. J Med Chem. 1990. PMID: 2194033

7

Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.

Rosenberg SH, Plattner JJ, Woods KW, Stein HH, Marcotte PA, Cohen J, Perun TJ. Rosenberg SH, et al. J Med Chem. 1987 Jul;30(7):1224-8. doi: 10.1021/jm00390a018. J Med Chem. 1987. PMID: 3298652

8

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.

Rosenberg SH, Spina KP, Woods KW, Polakowski J, Martin DL, Yao Z, Stein HH, Cohen J, Barlow JL, Egan DA, et al. Rosenberg SH, et al. J Med Chem. 1993 Feb 19;36(4):449-59. doi: 10.1021/jm00056a005. J Med Chem. 1993. PMID: 8474101

9

Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-72517).

Rosenberg SH, Spina KP, Condon SL, Polakowski J, Yao Z, Kovar P, Stein HH, Cohen J, Barlow JL, Klinghofer V, et al. Rosenberg SH, et al. J Med Chem. 1993 Feb 19;36(4):460-7. doi: 10.1021/jm00056a006. J Med Chem. 1993. PMID: 8474102

10

(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.

Fung AK, Baker WR, Fakhoury S, Stein HH, Cohen J, Donner BG, Garvey DS, Spina KP, Rosenberg SH. Fung AK, et al. Among authors: rosenberg sh. J Med Chem. 1997 Jul 4;40(14):2123-5. doi: 10.1021/jm970058x. J Med Chem. 1997. PMID: 9216829 No abstract available.

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