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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
Shamovsky I, de Graaf C, Alderin L, Bengtsson M, Bladh H, Börjesson L, Connolly S, Dyke HJ, van den Heuvel M, Johansson H, Josefsson BG, Kristoffersson A, Linnanen T, Lisius A, Männikkö R, Nordén B, Price S, Ripa L, Rognan D, Rosendahl A, Skrinjar M, Urbahns K. Shamovsky I, et al. Among authors: rosendahl a. J Med Chem. 2009 Dec 10;52(23):7706-23. doi: 10.1021/jm900713y. J Med Chem. 2009. PMID: 19954248
Small molecule antagonists of CCR8 inhibit eosinophil and T cell migration.
Karlsson AK, Walles K, Bladh H, Connolly S, Skrinjar M, Rosendahl A. Karlsson AK, et al. Among authors: rosendahl a. Biochem Biophys Res Commun. 2011 Apr 22;407(4):764-71. doi: 10.1016/j.bbrc.2011.03.097. Epub 2011 Mar 31. Biochem Biophys Res Commun. 2011. PMID: 21439940
Deletion of exon I of SMAD7 in mice results in altered B cell responses.
Li R, Rosendahl A, Brodin G, Cheng AM, Ahgren A, Sundquist C, Kulkarni S, Pawson T, Heldin CH, Heuchel RL. Li R, et al. Among authors: rosendahl a. J Immunol. 2006 Jun 1;176(11):6777-84. doi: 10.4049/jimmunol.176.11.6777. J Immunol. 2006. PMID: 16709837
126 results