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Targeting herpesvirus reliance of the chemokine system.
Rosenkilde MM, Kledal TN. Rosenkilde MM, et al. Curr Drug Targets. 2006 Jan;7(1):103-18. doi: 10.2174/138945006775270259. Curr Drug Targets. 2006. PMID: 16454703 Review.
A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.
Kledal TN, Rosenkilde MM, Coulin F, Simmons G, Johnsen AH, Alouani S, Power CA, Lüttichau HR, Gerstoft J, Clapham PR, Clark-Lewis I, Wells TN, Schwartz TW. Kledal TN, et al. Science. 1997 Sep 12;277(5332):1656-9. doi: 10.1126/science.277.5332.1656. Science. 1997. PMID: 9287217
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.
Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M. Signoret N, et al. J Cell Biol. 1997 Nov 3;139(3):651-64. doi: 10.1083/jcb.139.3.651. J Cell Biol. 1997. PMID: 9348282 Free PMC article.
The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies.
Ditzel HJ, Rosenkilde MM, Garred P, Wang M, Koefoed K, Pedersen C, Burton DR, Schwartz TW. Ditzel HJ, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5241-5. doi: 10.1073/pnas.95.9.5241. Proc Natl Acad Sci U S A. 1998. PMID: 9560260 Free PMC article.
Virally encoded 7TM receptors.
Rosenkilde MM, Waldhoer M, Lüttichau HR, Schwartz TW. Rosenkilde MM, et al. Oncogene. 2001 Mar 26;20(13):1582-93. doi: 10.1038/sj.onc.1204191. Oncogene. 2001. PMID: 11313905 Review.
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
Holst PJ, Rosenkilde MM, Manfra D, Chen SC, Wiekowski MT, Holst B, Cifire F, Lipp M, Schwartz TW, Lira SA. Holst PJ, et al. J Clin Invest. 2001 Dec;108(12):1789-96. doi: 10.1172/JCI13622. J Clin Invest. 2001. PMID: 11748262 Free PMC article.
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